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Fluorescence properties of curcumin-loaded nanoparticles for cell tracking. | LitMetric
Background : Posttransplant cell tracking, via stem cell labeling, is a crucial strategy for monitoring and maximizing benefits of cell-based therapies. The structures and functionalities of polysaccharides, proteins, and lipids allow their utilization in nanotechnology systems.Materials And Methods : In the present study, we analyzed the potential benefit of curcumin-loaded nanoparticles (NPC) using Vero cells (in vitro) and NPC-labeled adipose-derived mesenchymal stem cells (NPC-ADMSCs) (in vivo) in myocardial infarction and sciatic nerve crush preclinical models. Thereafter, transplantation, histological examination, real time imaging, and assessment of tissue regeneration were done.Results : Transplanted NPC-ADMSCs were clearly identified and revealed potential benefit when used in cell tracking.Conclusion : This approach may have broad applications in modeling labeled transplanted cells and in developing improved stem cell therapeutic strategies.
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