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Effects of intraperitoneal and intracerebroventricular injection of cinnamaldehyde and yohimbine on blood glucose and serum insulin concentrations in ketamine-xylazine induced acute hyperglycemia.
Vet Res Forum
June 2021
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
This study was designed to investigate the effects of peripheral [intraperitoneal (IP)] and central [intracerebroventricular (ICV)] administration of cinnamaldehyde on concentrations of blood glucose and serum insulin in the acute hyperglycemia induced by ketamine/xylazine. Yohimbine (a α-adrenoceptor antagonist) was used alone and in combination with cinnamaldehyde to explore the α-adrenergic receptor contribution. A total of 48 rats were divided into eight groups with six rats in each for IP administration of normal saline, vehicle, cinnamaldehyde (25.
View Article and Find Full Text PDFXylazine-induced reduction of tissue sensitivity to insulin leads to acute hyperglycemia in diabetic and normoglycemic monkeys.
BMC Anesthesiol
October 2013
Cardiovascular and Metabolic Disease Research, Crown Bioscience Inc, Science and Technology Park, 6 Beijing West Road, Taicang Economic Development Area, Jiangsu Province 215400, The People's Republic of China.
Background: The α2-adrenoceptor agonist xylazine as an anesthetic has been widely used either alone or in combination with other anesthetics, such as ketamine, in veterinary clinic and research. In the last decade xylazine has been used in drug abusers in certain geographic area. This study investigated the effects of xylazine on blood glucose level and insulin secretion in normoglycemic and insulin-dependent diabetic monkeys.
View Article and Find Full Text PDFNeurohormonal and metabolic effects of medetomidine compared with xylazine in healthy cats.
Can J Vet Res
April 2008
Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, Faculty of Agriculture, Tottori University, Koyama-Minami 4-101, Tottori 680-8553, Japan.
The purpose of this study was to investigate and compare the effects of medetomidine and xylazine on some neurohormonal and metabolic variables in healthy cats. Five cats were used repeatedly in each of 11 groups, which were injected intramuscularly with physiological saline solution (control), 20, 40, 80, 160, and 320 microg/kg of medetomidine, and 0.5, 1, 2, 4, and 8 mg/kg of xylazine.
View Article and Find Full Text PDFEffects of atipamezole, an alpha 2-adrenergic antagonist, and somatostatin on xylazine-induced growth hormone release in calves.
Endocr J
October 1996
Laboratory of Animal Reproduction, Faculty of Agriculture, Iwate University, Japan.
In order to clarify the mechanism of xylazine-induced GH release, we investigated the effects of atipamezole, a selective alpha 2-adrenergic antagonist, and somatostatin (SRIF) on xylazine-stimulated GH release in calves. Xylazine injection (0.30 mg/kg BW, iv) induced a rapid increase in the GH concentration.
View Article and Find Full Text PDFThe role of hypoxia in the hyperglycaemic effect of xylazine in sheep.
Zentralbl Veterinarmed A
April 1990
Department of Small and Large Animal Clinics, Veterinary School, University of Thessaloniki, Greece.
Xylazine (0.2 mg/kg, i.v.
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