Objective: I-131 mIBG scan semi-quantitative analysis with modified Curie and the International Society of Pediatric Oncology Europe Neuroblastoma (SIOPEN) scoring systems is helpful in the evaluation of disease extent and has prognostic impact in stage 4 neuroblastoma.
Methods: Retrospective, cross-sectional analysis of baseline I-131 mIBG scans in 21 patients with stage 4 or 4S neuroblastoma diagnosed between January 2007 and December 2015. All scans were assessed for Curie and SIOPEN scores. Distribution of scores was evaluated for risk factors i.e. age at diagnosis (>18 months) and early relapse (within 12 months). A curie score <2 and SIOPEN score <4 at diagnosis were correlated with event-free survival (EFS) and overall survival (OS).
Results: The data set comprised of 12 (57%) males and 9 (43%) females. Patients with age >18 months (n=9) at diagnosis or early relapse (n=9) had higher Curie [mean 5+7.5 standard deviation (SD), p=0.004] and SIOPEN (mean 5.2+10.8 SD, p=0.02) scores. Patients with a Curie score <2 and a SIOPEN score of <4 had better EFS and OS than patients with higher scores. Curie: 5-year EFS=Curie <2 (79%) versus Curie >2 (33%) (p=0.03); 5-year OS=Curie <2 (56%) versus Curie >2 (36%) (p=0.01). SIOPEN: 5-year EFS=SIOPEN <4 (70%) versus SIOPEN >4 (17%) (p=0.002); 5-year OS=SIOPEN <4 (58%) versus SIOPEN >4 (17%) (p=0.04). There was no statistically significant difference between the two scoring systems in terms of survival predictive value (Hazard ratio 2.38, 95% CI: 0.33-16.9, p=0.38).
Conclusion: I-131 mIBG Curie and SIOPEN scores have prognostication value in stage 4 neuroblastoma and should be routinely applied. Higher scores predict unfavorable prognosis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191737 | PMC |
| http://dx.doi.org/10.4274/mirt.52533 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Background: Dopamine transporter (I-FP-CIT) single-photon emission tomography (SPECT) and I-meta-iodobenzylguanidine (I-MIBG) image play roles as indicative biomarkers in diagnosing patients with dementia with Lewy bodies (DLB). Brain- and body-first subtypes of DLB were hypothesized implying that subset of DLB may have normal I-FP-CIT or I-MIBG results, respectively. The purpose of this study was to explore the diagnostic sensitivity of two combination imaging modalities (I-FP-CIT SPECT and I-MIBG image) in patients with DLB and examine the clinical difference between brain- and body-first subtype.
View Article and Find Full Text PDFBackground: Autopsy studies in Lewy Body Disease (LBD) indicate that cardiac sympathetic denervation precedes Lewy body pathology and neuronal loss in the brain. Myocardial 123I-metaiodobenzylguanidine (MIBG) scintigraphy noninvasively assesses postganglionic cardiac sympathetic denervation in LBD and is considered an important biomarker in the international diagnostic criteria of Dementia with Lewy Bodies and Parkinson's Disease (PD). Despite the internationally recognized importance of MIBG scintigraphy in LBD, its use in neurodegenerative disorders is not FDA approved for this indication and is rarely used in the US for neurological research.
View Article and Find Full Text PDFGastric emptying time and its correlation with cardiac MIBG in body-first and brain-first subtype Parkinson's disease.
J Neurol
December 2024
Department of Neurology, Ajou University School of Medicine, Suwon, Republic of Korea.
Introduction: Recently, "body-first" and "brain-first" subtype in Parkinson's disease (PD) was proposed based on the propagation of α-synuclein. In isolated RBD considered as a premotor stage of body-first PD, α-synuclein was supposed to originate in the enteric nervous system and spreads via autonomic nervous system. Therefore, we hypothesized that body-first PD is more likely to have a delayed gastric emptying time and reduced cardiac sympathetic denervation.
View Article and Find Full Text PDFValidation of the SIMIND simulation code using the myocardial phantom HL.
Biomed Phys Eng Express
December 2024
Department of Radiological Technology, Gunma Prefectural College of Health Sciences, Maebashi, Japan.
Article Synopsis
- This study evaluates the effectiveness of SIMIND, a Monte Carlo simulation tool, as an alternative for modeling nuclear medicine experiments, specifically using a cardiac phantom to mimic human heart structures.
- Both simulated and experimental data were analyzed, focusing on various energy windows and regions of interest (ROIs), revealing that SIMIND produced favorable results with relative errors under 10% in most cases, although some areas showed larger discrepancies.
- The findings suggest that while SIMIND can effectively simulate nuclear medicine experiments, accuracy may be compromised in certain scenarios, particularly in low and high-energy subwindows.
Recommendations for the use of nuclear medicine imaging in patients with neuroblastoma.
Clin Transl Oncol
November 2024
Servicio de Hemato-Oncología Pediátrica, Hospital Universitario La Paz, Madrid, Spain.
Neuroblastoma (NB) is the most common extracranial solid cancer in children. Despite intensive multimodality treatment, long-term survival of patients with high-risk NB, which comprises more than half of all cases, remains poor. Nuclear medicine is key in diagnosis, staging, response assessment and long-term follow-up of NB.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!