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A low-dose prebiotic fiber supplement reduces lipopolysaccharide-binding protein concentrations in a subgroup of young, healthy adults consuming low-fiber diets.
Nutr Res
December 2024
Department of Nutrition, University of California, Davis, CA, USA. Electronic address:
Although the beneficial effects of fiber supplementation on overall health and the gut microbiome are well-known, it is not clear whether fiber supplementation can also alter the concentrations of lipopolysaccharide-binding protein (LBP), a marker of intestinal permeability. A secondary analysis of a previously conducted study was performed. In the randomized-order, placebo-controlled, double-blinded, cross-over study 20 healthy, young participants consuming a low-fiber diet at baseline were administered a daily dose of 12 g of prebiotic fiber compared with a placebo over a period of 4 weeks with a 4-week washout between arms.
View Article and Find Full Text PDFGestational Exposure to Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Childhood.
JAMA Pediatr
December 2024
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Importance: Gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) may increase the risk of adverse fetal kidney outcomes. However, details regarding timing, specific NSAIDs, and long-term childhood kidney outcomes are limited.
Objective: To evaluate the association between gestational exposure to NSAIDs and the risk of chronic kidney disease (CKD) in childhood.
Physicians' attitudes toward gastroprotective strategies for nonsteroidal anti-inflammatory drug prescription.
Proc (Bayl Univ Med Cent)
November 2024
Division of Gastroenterology and Hepatology, Case Western Reserve University, Cleveland, Ohio, USA.
Introduction: There is a paucity of information regarding providers' attitudes toward gastric-protective strategies with concurrent use of nonsteroidal anti-inflammatory drugs (NSAIDs). We aimed to assess gastric-protective strategies used upon prescribing NSAIDs and providers' awareness of societal guidelines for preventing NSAID-induced gastric complications.
Methods: A standardized 10-item questionnaire was sent to all orthopedic providers in North Carolina and South Carolina.
Wastewater-based monitoring of antipyretics use during COVID-19 outbreak in China and its associated ecological risks.
Environ Res
December 2024
Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, 100871, Beijing, PR China. Electronic address:
At the end of 2022, a sudden policy shift in China triggered an unprecedented COVID-19 outbreak that led to a dramatic increase in the consumption of antipyretics. In this study, the occurrence of the two most commonly used antipyretics (ibuprofen and paracetamol) and their metabolites were analyzed in the wastewater of nine major cities in China, covering the periods before, during, and after the policy change. The remarkable surge after the policy change for ibuprofen and paracetamol reached 67 times (in Nanning) and 311 times (in Lanzhou) compared to pre-pandemic levels, respectively.
View Article and Find Full Text PDFEnantioselective Toxicity of Ibuprofen to Earthworms: Unraveling the Effect and Mechanism on Enhanced Toxicity of -Ibuprofen Over -Ibuprofen.
Environ Sci Technol
December 2024
State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China.
With the global implementation of wastewater reuse, accurately assessing the soil ecological risk of chiral pollutants from wastewater necessitates a comprehensive understanding of their enantioselective toxicity to soil animals. Ibuprofen (IBU) is the most prevalent chiral pharmaceutical in municipal wastewater. However, its enantioselective toxicity toward soil animals and the underlying mechanism remain largely unknown.
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