AI Article Synopsis
- About 3 million people die annually from ambient air pollution, highlighting its severe health impacts.
- Most research on particulate matter (PM) has focused on respiratory and cardiovascular issues, leaving a knowledge gap regarding its effects on kidney function.
- The study found that sub-chronic PM exposure caused significant kidney damage in rats, especially in hypertensive models, indicating that even low levels of PM can negatively affect renal health.
Article Abstract
According to the WHO, about 3 million people die each year due to ambient air pollution. Most of the in vivo studies on the PM effects have been done on respiratory and cardiovascular tissues. However, little is known about the effects on the tissues involved on xenobiotic removal, such as kidneys. In the present study we assess the harmful effects of sub-chronic exposure to PM on the kidney, by investigating histologic and serum alterations in healthy and hypertensive rat models. Mean PM concentrations during exposures were slightly above the daily WHO standard. Exposed animals showed fibrosis, mesangial expansion, decrease glomerular and tubular lumen volumes in kidneys, with an elevated BUN. Hypertensive animals also exhibited much more severe alterations than healthy animals. We conclude that PM induces minimal or small-scale abnormalities that can be determinant for renal health preservation.
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| http://dx.doi.org/10.1016/j.envint.2018.10.007 | DOI Listing |
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