In this work, we present a novel approach to explore future trajectories in urban drainage systems, emphasizing the adoption and implementation of sustainable 'nature-based' stormwater management strategies. The focus is on the development and long-term assessment of socio-technical pathways to create a multifunctional stormwater system at the city scale. The innovation is to identify and represent the socio-technical pathways by means of adoption curves for such transition processes. We combine urban planning policies and state-of-the-art urban engineering approaches with societal aspects and analyze them with traditional biophysical models (hydrologic-hydraulic sewer modeling). In doing so, different pathways from a current to a future system state are investigated under a variety of political, population and climate scenarios. Results allow for strategy screening by addressing the spatial and temporal implementation of decentralized stormwater control measures, to enable a successful transition to a sustainable future city. The model is applied to an ongoing transition of Kiruna, a city in Sweden, considering 36 different future trajectories over a transition period of 23 years. Results show that the trajectory of raingarden implementation under a sustainability policy can alleviate the adverse effects of urbanization (growth scenario). While this trajectory resulted in, for example, nearly the same sewer surcharge performance as that characterized by declining urbanization (stagnation) and a business-as-usual policy (with expected raingarden uptake rates approximately one-third lower), significantly better ecological performances (e.g. runoff treatment ratios up to 50%) are achieved.
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http://dx.doi.org/10.1016/j.scitotenv.2018.10.061 | DOI Listing |
Epilepsia
January 2025
Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada.
We propose and prioritize important outcome domains that should be considered for future research investigating long-term outcomes (LTO) after new onset refractory status epilepticus (NORSE). The study was led by the international NORSE Institute LTO Working Group. First, literature describing the LTO of NORSE survivors was identified using a PubMed search and summarized to identify knowledge gaps.
View Article and Find Full Text PDFBiophys J
January 2025
Department of Chemistry, Chicago Center for Theoretical Chemistry, The James Franck Institute, and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, United States. Electronic address:
Microtubules (MTs) constitute the largest components of the eukaryotic cytoskeleton and play crucial roles in various cellular processes, including mitosis and intracellular transport. The property allowing MTs to cater to such diverse roles is attributed to dynamic instability, which is coupled to the hydrolysis of GTP (guanosine-5'-triphosphate) to GDP (guanosine-5'-diphosphate) within the β-tubulin monomers. Understanding the equilibrium dynamics and the structural features of both GDP- and GTP-complexed MT tips, especially at an all-atom level, remains challenging for both experimental and computational methods because of their dynamic nature and the prohibitive computational demands of simulating large, many-protein systems.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
January 2025
Vrije Universiteit Brussel, Brussels Health Centre, Brussels, Belgium.
Purpose: Cochlear implants (CI) are the most successful bioprosthesis in medicine probably due to the tonotopic anatomy of the auditory pathway and of course the brain plasticity. Correct placement of the CI arrays, respecting the inner ear anatomy are therefore important. The ideal trajectory to insert a cochlear implant array is defined by an entrance through the round window membrane and continues as long as possible parallel to the basal turn of the cochlea.
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
Davidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
The sustainable management of polydiene waste represents a formidable challenge in the realm of polymer chemistry, given the extensive industrial utilization of polydienes due to their superior elastomeric properties. This comprehensive Perspective addresses the multifaceted obstacles hindering efficient recycling of polydienes, encompassing environmental concerns, technical limitations, and economic disincentives. We systematically dissect the influence of polydienes' chemical structures on their recyclability, tracing the evolution of polydiene utilization and disposal practices while assessing the current landscape of waste management strategies.
View Article and Find Full Text PDFKidney Med
November 2024
Division of Geriatrics and Extended Care, Edward Hines, Jr. VA Hospital, Hines, IL.
Rationale & Objective: Engaging patients with advanced chronic kidney disease (CKD) in goals of care (GOC) conversations is essential to align life-sustaining treatments with patient preferences. This pilot study described the feasibility of engaging older Veterans with advanced CKD in GOC conversations via telehealth by (1) comparing patient characteristics, including life-sustaining treatment note completion rates and preferences by visit modality, and (2) exploring Veteran and clinician perspectives surrounding telehealth GOC conversations.
Study Design: Mixed-method convergent design including a prospective, quantitative observational cohort analysis (n = 40) and qualitative, semi-structured interviews with 4 clinicians and 11 Veterans.
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