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Caution for Multidrug Therapy: Significant Baroreflex Afferent Neuroexcitation Coordinated by Multi-Channels/Pumps Under the Threshold Concentration of Yoda1 and Dobutamine Combination.
Biomolecules
October 2024
State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology (State Key Laboratory-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin 150081, China.
Multi-drug therapies are common in cardiovascular disease intervention; however, io channel/pump coordination has not been tested electrophysiologically. Apparently, inward currents were not elicited by Yoda1/10 nM or Dobutamine/100 nM alone in Ah-type baroreceptor neurons, but were by their combination. To verify this, electroneurography and the whole-cell patch-clamp technique were performed.
View Article and Find Full Text PDFRisk Factors and Predictors of Prolonged Mechanical Ventilation Following Cardiac Surgery: A Narrative Review.
Cureus
August 2024
Internal Medicine, Tbilisi State Medical University, Tbilisi, GEO.
The subset of patients requiring prolonged mechanical ventilation is significantly high worldwide, making it an important topic of continuous and ongoing research. Over the years, various articles have shown that there may be predictors of prolonged ventilation that could be applied in healthcare to make it more patient-centered. The available literature suggests that authors have different definitions of "prolonged" ventilation.
View Article and Find Full Text PDFImpact of device variability and protocol differences on kidney function during normothermic machine perfusion: A comparative study using porcine and human kidneys.
Artif Organs
January 2025
Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Introduction: A growing interest in renal normothermic machine perfusion (NMP) has resulted in more clinically available perfusion devices. While all perfusion systems have the same aim, there are significant differences in their circuits, pumps, sensors, and software. Therefore, our objective was to assess the impact of different perfusion protocols and devices on kidney function and perfusion parameters during NMP.
View Article and Find Full Text PDFRhodamine 19 Alkyl Esters as Effective Antibacterial Agents.
Int J Mol Sci
June 2024
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119991 Moscow, Russia.
Mitochondria-targeted antioxidants (MTAs) have been studied quite intensively in recent years as potential therapeutic agents and vectors for the delivery of other active substances to mitochondria and bacteria. Their most studied representatives are MitoQ and SkQ1, with its fluorescent rhodamine analog SkQR1, a decyl ester of rhodamine 19 carrying plastoquinone. In the present work, we observed a pronounced antibacterial action of SkQR1 against Gram-positive bacteria, but virtually no effect on Gram-negative bacteria.
View Article and Find Full Text PDFA fluid-structure interaction simulation on the impact of transcatheter micro ventricular assist devices on aortic valves.
Comput Methods Programs Biomed
September 2024
Department of Engineering Mechanics, School of Aerospace Engineering, Tsinghua University, Beijing 100084, China. Electronic address:
Background And Objective: The implantation of ventricular assist devices (VADs) has become an important treatment option for patients with heart failure. Aortic valve insufficiency is a common complication caused by VADs implantation. Currently, there is very little quantitative research on the effects of transcatheter micro VADs or the intervention pumps on the aortic valves.
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