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Development and Selection of Candidate Monoclonal Antibodies for the Detection of Clostridium botulinum Neurotoxin Serotype B Light Chain.
Protein Expr Purif
January 2025
Institute of Tropical Medicine, Joint Vietnam-Russia Tropical Science and Technology Research Center.
Botulinum neurotoxin, produced by the bacterium Clostridium botulinum, causes botulism, a severe, rapidly progressing, and potentially fatal condition. Swift detection of the toxin and timely administration of antitoxin antibodies are critical for effective treatment. The current standard for Botulinum toxin testing is the mouse lethality assay, but this method is time-consuming and requires live animals.
View Article and Find Full Text PDFElevated incidence of infant botulism in a 17-county area of the Mid-Atlantic region in the United States, 2000-2019, including association with soil types.
Appl Environ Microbiol
November 2024
Department of Ecosystems Science and Management, Pennsylvania State University, University Park, Pennsylvania, USA.
Unlabelled: We sought to identify counties in the northeastern United States where the incidence of infant botulism (IB) is elevated compared to the nationwide incidence and to assess associations with soil type at the case residence. IB cases were identified through the distribution of the orphan drug Human Botulism Immune Globulin Intravenous for treatment of IB by state and national surveillance systems and were subsequently confirmed by laboratory testing. IB incidence by county was calculated as the number of IB cases divided by the number of live births in the county from 2000 to 2019.
View Article and Find Full Text PDFCollaborative wildlife disease outbreak investigation and response at Bells Swamp Victoria, February 2023.
Aust Vet J
October 2024
Wildlife Health Victoria: Surveillance, Melbourne Veterinary School, The University of Melbourne, Melbourne, Victoria, Australia.
In February 2023, a report of morbidity and mortality in waterbirds triggered a collaborative regional wildlife disease outbreak investigation and response, led by Parks Victoria. Triage, rehabilitation and diagnosis of sick and dead birds were undertaken by Zoos Victoria (ZV), Agriculture Victoria, Vets for Compassion, Wildlife Victoria and Melbourne Veterinary School (MVS). The field response focused on collection of sick and dead birds for wildlife welfare, for diagnosis, and to reduce environmental contamination.
View Article and Find Full Text PDFAn outbreak of botulism on a pig farm due to the newly described Clostridium botulinum type C.
Anaerobe
October 2024
ANSES, Ploufragan-Plouzané-Niort Laboratory, Epidemiology, Health and Welfare Unit, 22440, Ploufragan, France.
This study reports a botulism outbreak on a pig farm. Clostridium botulinum type C was detected using PCR. The gene encoding the toxin corresponds to a novel type C neurotoxin recently described in a human botulism outbreak, raising the question of its prevalence in pigs and the related risks to humans.
View Article and Find Full Text PDFWould you bet on the vet? Influences on dairy farmers' vaccination choices, with a spotlight on the Veterinarian impact.
Prev Vet Med
September 2024
Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot 76100, Israel. Electronic address:
Ensuring effective vaccination is crucial for epidemic control, particularly in voluntary vaccination scenarios. Though highly important for planning voluntary vaccination programs, we lack insights into the effectiveness of veterinarian communication and the impact of disease-specific traits on farmer vaccination intentions. To fill this void, our study compared five diseases affecting Israeli dairy cattle (Botulism, Bovine Ephemeral Fever (BEF), Brucellosis, Lumpy Skin Disease (LSD), and Rabies).
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