Collagens are the most abundant vertebrate extracellular matrix proteins. They form a superfamily of 28 members that show a remarkable diversity in molecular and supramolecular organization, tissue distribution and function and mutations in collagen genes result in a wide range of inherited connective tissue diseases. In the recent years, unexpected and very diverse regulatory and mechanical collagen functions have been reported. But the structural and functional landscape of the collagen superfamily is still far from being complete. Zebrafish has emerged over the last decades as a powerful model to interrogate gene function and there are numerous advantages of using zebrafish for collagen research, including recent advances in genome editing technologies and the characterization of the zebrafish matrisome. One can confidently predict that zebrafish will rapidly become a popular vertebrate model to investigate the role of collagens in development, disease and regeneration as discussed in this chapter.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.semcdb.2018.10.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Characteristic Muscle Quality Parameters of Male Largemouth Bass () Distinguished from Female and Physiological Variations Revealed by Transcriptome Profiling.
Biology (Basel)
December 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Male largemouth bass () are often overlooked because females grow faster. We explored the value of male largemouth bass by comparing muscle nutrition, texture, and transcriptomes between males and females. Females grew faster than males ( < 0.
View Article and Find Full Text PDFSargassum glaucescens Extract/Marine-Derived Collagen Blend Sponge and Their Properties for Wound Healing.
Mar Biotechnol (NY)
January 2025
Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
Burn wounds are challenging to treat due to considerable tissue damage and fluid loss. Creating wound dressings from natural and biological materials makes it possible to treat wounds and promote rapid epithelialization to speed healing and restore skin function. As a result, the ability of a collagen scaffold (Col) made from rainbow trout (Oncorhynchus mykiss) and putative bioactive phytochemical components from a Sargassum glaucescens (S.
View Article and Find Full Text PDFComparative transcriptome analysis of albino northern snakehead (Channa argus) reveals its various collagen-related DEGs in caudal fin cells.
PLoS One
December 2024
College of Life Sciences, Neijiang Normal University, Neijiang, China.
The albino northern snakehead (Channa argus) is an aquaculture species characterized by heritable albino body color, in contrast to the typical coloration. Additionally, there are gray- and golden-finned individuals, which exhibit distinct coloration in their caudal fins. We performed RNA-seq to profile the transcriptome of caudal fin tissues in albino gray-finned and golden-finned C.
View Article and Find Full Text PDFCharacterization of yellowfin tuna (Thunnus albacares) skin gelatin extracted by bromelain hydrolysis and ultrasound pre-treatment.
J Food Sci
January 2025
Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Gadjah mada University, Yogyakarta, Indonesia.
Article Synopsis
- The study explores using hydrolysis of yellowfin tuna skin waste as an eco-friendly method to produce gelatin, and highlights ultrasound pre-treatment as a way to enhance extraction efficiency.
- Factors like ultrasound amplitude, pre-treatment duration, enzyme concentration, and hydrolysis time were tested to determine optimal conditions for maximizing yield and quality of gelatin, which resulted in specific optimal parameters.
- The final gelatin showed promising properties such as high viscosity, gel strength, emulsifying abilities, antioxidant activity, and good digestibility, marking a step towards sustainable gelatin production from fish waste.
Novel peptide inhibitor of matrix Metalloproteinases-1 from pufferfish skin collagen hydrolysates and its potential Photoprotective activity via the MAPK/AP-1 signaling pathway.
J Photochem Photobiol B
January 2025
Fisheries Research Institute of Fujian, National Research and Development Center for Marine Fish Processing, Key Laboratory of Cultivation and High-value Utilization of Marine Organisms in Fujian Province, Xiamen, China. Electronic address:
Takifugu bimaculatus, a pufferfish species farmed in Fujian Province, is known for its non-toxic flesh and collagen-rich skin. We identified a novel collagen-derived matrix metalloproteinase 1 (MMP-1) inhibitory peptide, from T. bimaculatus skin with potent anti-photoaging properties.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!