In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243676 | PMC |
| http://dx.doi.org/10.1039/c8cc05113e | DOI Listing |
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