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Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report. | LitMetric
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Drug-drug interactions among drugs prescribed for nontuberculous mycobacterial infection and epilepsy: A case report.

Naoki Yoshikawa Tomoya Tazaki Mari Hatanaka Yasuharu Oda Nobuhiro Matsumoto Junichiro Sonoda Ryuji Ikeda

J Clin Pharm Ther

Department of Pharmacy, University of Miyazaki Hospital, Miyazaki, Japan.

Published: February 2019

What Is Known And Objective: Multi-drug combinations often make chemotherapy difficult owing to drug-drug interactions (DDIs). We report a rare and difficult-to-treat case due to DDIs between drugs for Mycobacterium avium complex (MAC) infection and antiepileptic drugs.

Case Description: A 70-year-old Japanese woman was diagnosed as having pulmonary MAC disease. She had a history of symptomatic epilepsy, which was successfully treated with phenytoin and phenobarbital. Serum phenytoin concentrations increased upon the initiation of MAC infection treatment.

What Is New And Conclusion: We evaluated DDIs and adjusted the dosage of drugs by monitoring the serum drug level.

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 Source
http://dx.doi.org/10.1111/jcpt.12764DOI Listing

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