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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170310 | PMC |
| http://dx.doi.org/10.5045/br.2018.53.3.188 | DOI Listing |
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Acute lymphoblastic leukemia with pseudo-Chediak-Higashi granules in the initial diagnosis and relapse.
Int J Lab Hematol
October 2024
Department of Laboratory Medicine, Kumming Children's Hospital, Kumming, Yunnan, China.
Pseudo-Chediak-Higashi granules are large cytoplasmic inclusions commonly encountered in myeloblasts or other myeloid precursors in acute myeloid leukemia and myelodysplastic syndromes. However, pseudo-Chediak-Higashi granules are rarely found in acute lymphoblastic leukemia (ALL). We present the case of an 8-year-old boy who was diagnosed with ALL with pseudo-Chediak-Higashi granules in the initial diagnosis and relapse, acting like a characteristic marker.
View Article and Find Full Text PDFBackground: Defined as rare large azurophilic cytoplasmic inclusions, Pseudo-Chediak-Higashi granules mimic those in granulocytes cytoplasm of Chediak-Higashi syndrome. Rare cases of hematopoietic and lymphoid tissues tumors showed Pseudo-Chediak-Higashi inclusions in cytoplasm, some of which presented with unusual morphological characteristics.
Methods: Herein, we report the first case, in which rare pseudo-Chediak-Higashi inclusions were observed in therapy-related acute myeloid leukemia with myelodysplasia-related changes (t-AML-MRC).
Background: The aim of the study was to improve the understanding of complex karyotype acute mixed cell leukemia containing pseudo Chediak-Higashi granules.
Methods: A case of acute mixed cell leukemia resembling AML1-ETO positive acute myeloid leukemia was reported. The results of morphological, immunophenotypic, and cytogenetic tests were analyzed by reviewing relevant literature.
Pseudo-Chediak-Higashi Granules in a Case of Acute Lymphoblastic Leukemia Mimicking Acute Myeloid Leukemia.
Turk J Haematol
August 2022
Jianshe Road 38 Longhua District Shenzhen Guangdong Province, Shenzhen, China
Relapsed RUNX1-RUNX1T1-positive acute myeloid leukemia with pseudo-Chediak-Higashi granules.
Int J Hematol
May 2021
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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