. GATA3-positive sarcomatoid carcinoma has never been documented in the past. It is a case of aggressive tumor, positive for GATA3, which should be further studied for its prognostic and therapeutic significance.
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http://dx.doi.org/10.1155/2018/6469591 | DOI Listing |
Hum Pathol
May 2023
Department of Pathology, Yale University School of Medicine, New Haven, CT, 06510, USA; Yale Cancer Center, Yale University School of Medicine, New Haven, CT, 06510, USA.
This study assessed the expression of GATA3 in primary lung carcinomas and correlated it with tumor histology and immunostains routinely utilized in the work up of primary lung cancers. Tissue microarrays (TMAs) were constructed from a cohort of 184 non-small cell carcinomas, stained with GATA3, p40, TTF-1, and napsin A, and analyzed semi-quantitatively. All TMA cases with GATA3 expression were further analyzed using corresponding whole slide sections.
View Article and Find Full Text PDFCase Rep Oncol Med
September 2018
Department of Medicine, Med Star Good Samaritan Hospital, Baltimore, MD 21234, USA.
. GATA3-positive sarcomatoid carcinoma has never been documented in the past. It is a case of aggressive tumor, positive for GATA3, which should be further studied for its prognostic and therapeutic significance.
View Article and Find Full Text PDFAm J Surg Pathol
September 2014
Departments of *Pathology †Surgery, Section of Urology, University of Chicago, Chicago, IL ‡Department of Pathology, University of Arkansas, Little Rock, AK §Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, Cordoba University, Cordoba, Spain ∥Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH.
The pseudoangiosarcomatous pattern has been described mostly in cutaneous and some visceral squamous cell carcinomas and is unique for its striking morphologic resemblance to angiosarcoma. Herein, we describe the clinicopathologic features of 7 pseudoangiosarcomatous urothelial carcinomas that occurred in the urinary bladder. The patients included 6 men and 1 woman ranging in age from 47 to 87 years (median 70 y).
View Article and Find Full Text PDFHum Pathol
August 2013
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD 21231, USA.
Immunohistochemistry for PAX8 and GATA3 are sensitive markers for renal cell carcinoma and urothelial carcinoma, respectively. However, there are limited data on these markers in sarcomatoid renal cell carcinoma (SARCRCC) and sarcomatoid urothelial carcinoma (SARCUC). Tissue microarrays (TMAs) were constructed from 45 cases of SARCRCC and 45 cases of SARCUC of the lower urinary tract, with an additional 11 SARCUCs of the upper tract.
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