AI Article Synopsis
- The study investigates the link between environmental factors, particularly chlorine anions and organochlorine chemicals, and the occurrence of congenital malformations (CMs) in 399 municipalities in Paraná, Brazil.
- Researchers measured chemical concentrations and agricultural outputs from 2006 to 2010, analyzing data on nearly 1.2 million newborns to determine the prevalence of CMs.
- Results indicated that higher chlorine levels in the water were associated with increased CM density, particularly in regions with significant agricultural activity, suggesting that these environmental factors may contribute to harmful developmental outcomes in newborns.
Article Abstract
The incidence of variable congenital malformation (CM) among 399 municipalities in the state of Paraná, southern Brazil, suggests the etiological role of environmental factors. This study examined a) environmental concentrations of chlorine anions (Cl) associated with organochlorines (OCs) and b) associations between these chemicals and agricultural output with CMs using a geographical information system. In one of the three years during the sampling period (2008, 2009 or 2010) Cl, dichlorodiphenyltrichloroethane (p,p'-DDT), dichlorodiphenyldichloroethylene (p,p'-DDE), dichlorodiphenyldichloroethane (p,p'-DDD), and endosulfan levels were measured in 465 (465/736, 63%) catchment basins. Agricultural outputs for crops during 2006-2010 were also evaluated (t/km). Further, CM kernel density for the 399 municipalities in Paraná during 2007-2014 was investigated. Cl levels increased significantly in one of the three years (2008, 2009 or 2010) in western catchment basins, compared to 1996 (p < 0.0001). The municipalities were divided according to the obtained Cl levels, where sub-region C2 (central-southern) < 1.8 mg/L ≤ sub-regions C1 (northern-western) and C3 (eastern-southern). We identified 8756 cases of CMs among 1,221,287 newborns (NB) in all sub-regions. C1 had higher DDT-DDE-DDD (p,p'-DDT + p,p'-DDE + p,p'-DDD) concentrations, agricultural output, and CM kernel density. C2 and C3 had minor agricultural outputs (per square kilometer) and CM densities. A 2.96 mg/L increase in Cl between sub-regions C1 and C2 was co-localized with a 45% increase in CM density (spatial relative risk = 1.45, CI 95%: 1.36-1.55). C1 had the highest log likelihood ratios (p = 0.001) identified via SaTScan clustering analyses. Organochlorines and other toxic chlorinated chemicals may contribute to CMs in humans, and these chemicals are ultimately transformed and release Cl in rivers. Higher Cl levels were correlated significantly with higher agricultural productivity, DDT-DDE-DDD levels, and CMs in some parts of the northern and western sub-regions (C1).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.scitotenv.2018.09.061 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genetic and Clinical-epidemiologic Profile of hRSV in Pediatric Patients in Southern Brazil: A Four-year Hospital Surveillance Study.
Pediatr Infect Dis J
December 2024
Public Health Laboratory, Secretaria de Saúde do Estado do Paraná, Curitiba, Brazil.
Background: Respiratory syncytial virus (hRSV) infections primarily cause acute respiratory illness and pediatric hospitalizations. We examined the hRSV molecular epidemiology in a pediatric cohort over a 4-year period and described the interrelationship with clinical data.
Methods: A cross-sectional study was conducted from 2014 to 2017 on children with acute respiratory illness.
Diagnosis of spp. in ruminants at Southern Brazil.
Braz J Vet Med
December 2024
Veterinarian, Laboratório do Grupo de Estudos em Enfermidades Parasitárias, Departamento de Veterinária Preventiva, Universidade Federal de Pelotas, Pelotas, Rio Grande do Sul, Brazil.
spp. is a flagellated protozoan that parasitizes the small intestine of various mammals, birds, and amphibians, being transmitted via the fecal-oral route. Giardiasis is one of the most prevalent parasitic diseases in both developed and developing countries, with a prevalence of 0,1-5% and 20-30%, respectively, and is correlated with poor hygiene practices, such as irregular handwashing, which consequently contaminates food when handled.
View Article and Find Full Text PDFMorphological and cellular effects in Boana faber tadpoles (Anura: Hylidae) exposed to atrazine-based herbicide and glyphosate-based herbicide and their mixtures.
Environ Sci Pollut Res Int
December 2024
Laboratório de Ecologia e Conservação, Universidade Federal da Fronteira Sul, Campus Erechim, RS 135 - km 72, nº 200, Erechim, RS, Brazil.
Atrazine and glyphosate are considered some of the main pollutants for aquatic ecosystems, directly and indirectly affecting non-target organisms, such as amphibians. This study aimed to evaluate the sublethal effects of different concentrations of atrazine-based herbicide (ABH) and glyphosate-based herbicide (GBH) commercial formulations, both individually and in a mixture, through toxicity tests on the larval stage of Boana faber. Tadpoles were exposed to concentrations of ABH (2, 9.
View Article and Find Full Text PDFProtective effects of different exercise modalities on oxidative stress in animal models of high intraocular pressure and diabetes.
Exp Eye Res
December 2024
Department of Biochemistry, Post-Graduate Program in Biochemistry and Post-Graduate Program in Pharmacology, Federal University of Santa Catarina (UFSC), Florianópolis, Santa Catarina, Brazil. Electronic address:
High intraocular pressure (HIOP) and high glucose levels are associated with oxidative stress. Although physical exercise protects against oxidative damage, its specific impact on eye health remains unclear. Thus, this study aimed to assess the impact of physical exercise on the oxidative status of whole eyes in male Swiss mice subjected to HIOP model and cafeteria diet (CD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!