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Evaluating low NO hydrogen engines designed for off-road and construction applications.
Environ Sci Process Impacts
January 2025
Wolfson Atmospheric Chemistry Laboratories, University of York, Heslington, York, YO10 5DD, UK.
Hydrogen internal combustion engines offer a near-term decarbonisation pathway for hard to electrify sectors such as non-road mobile machinery (NRMM). However, few hydrogen-specific engines have ever been developed with the twin-goals of maximising low carbon energy efficiency and delivering air quality co-benefits. We present analyses of dynamometer-derived nitrogen oxides (NO) tailpipe emissions from four variants of a ∼55 kW four-cylinder port fuelled injection spark ignition hydrogen internal combustion engine (H2ICE) suitable for a range of uses within the NRMM industry.
View Article and Find Full Text PDFAn Injectable Alginate Hydrogel Modified by Collagen and Fibronectin for Better Cellular Environment.
ACS Appl Bio Mater
January 2025
Division of Plastic Surgery, Department of Surgery, Yale School of Medicine, Yale University, 310 Cedar Street, New Haven, Connecticut 06510, United States.
Encapsulating fibroblasts in alginate hydrogels is a promising strategy to promote wound healing. However, improving the cell function within the alginate matrix remains a challenge. In this study, we engineer an injectable hydrogel through mixing alginate function with collagen and fibronectin, creating a better microenvironment for enhancing fibroblast function and cytokine secretion.
View Article and Find Full Text PDFP2X7R antagonism suppresses long-lasting brain hyperexcitability following traumatic brain injury in mice.
Theranostics
January 2025
Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland.
Post-traumatic epilepsy (PTE) is one of the most common life-quality reducing consequences of traumatic brain injury (TBI). However, to date there are no pharmacological approaches to predict or to prevent the development of PTE. The P2X7 receptor (P2X7R) is a cationic ATP-dependent membrane channel that is expressed throughout the brain.
View Article and Find Full Text PDFAstragaloside IV alleviates GDM via regulating gut microbiota and gut microbiota metabolomic.
Front Pharmacol
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Department of Obstetrics, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China.
Background: Gestational diabetes mellitus (GDM), a severe pregnancy disorder, is a temporary form of diabetes that occurs during gestation. Astragaloside IV (AS IV), a natural and effective composition of , shows pharmacological effects against diabetes. On the contrary, the effects of AS IV on GDM development are still not clear.
View Article and Find Full Text PDFVariations in Neuromuscular Functions After Platelet-Rich Plasma and Dextrose Injections in Chronic Lateral Epicondylitis: A Randomized Controlled Study.
Sports Health
January 2025
Institute of Allied Health Sciences, College of Medicine, National Cheng-Kung University, Tainan, Taiwan.
Background: Lateral epicondylitis is caused by overuse and manifests as pain, weakness, and difficulty with object manipulation. Platelet-rich plasma (PRP) and dextrose injections have shown promise in reducing pain and improving function.
Hypothesis: PRP is more effective for force precision control of the extensor carpi radialis brevis (ECRB) muscle than dextrose injection for patients with chronic lateral epicondylitis (CLE).
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