Early detection of microbial patterns is a hallmark of innate immunity and essential for clearance of invading pathogens. A recent Nature publication by Zhou et al. (2018) has uncovered ALPK1 as a pattern recognition receptor for Gram-negative bacteria triggering NF-κB activation and identified the bacterial sugar ADP-Hep as its ligand.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510543 | PMC |
| http://dx.doi.org/10.1016/j.chom.2018.09.017 | DOI Listing |
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