AI Article Synopsis
- A new method for the selective borylation of aromatic amides has been developed, showing that unlike esters which borylate at the para position, amides preferentially borylate at the meta position.
- To achieve high selectivity for the meta position, researchers used an L-shaped bifunctional ligand that interacts with the oxygen of the amide's carbonyl group.
- This unique interaction enhances the control needed for the meta C-H activation and borylation process.
Article Abstract
A new concept for the meta-selective borylation of aromatic amides is described. It has been demonstrated that while esters gave para borylations, amides lead to meta borylations. For achieving high meta selectivity, an L-shaped bifunctional ligand has been employed and engages in an O⋅⋅⋅K noncovalent interaction with the oxygen atom of the moderately distorted amide carbonyl group. This interaction provides exceptional control for meta C-H activation/borylation.
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| http://dx.doi.org/10.1002/anie.201809929 | DOI Listing |
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