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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355848 | PMC |
| http://dx.doi.org/10.1038/s41423-018-0171-3 | DOI Listing |
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Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) locus is unique in carrying two super-enhancers at both ends of the constant gene cluster: the 5'E super-enhancer promotes VDJ recombination during the earliest steps of B-cell ontogeny while the 3' regulatory region (3'RR) is essential for late differentiation.
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