Objective: To determine the risk factors for extubation failure in the intensive care unit.
Methods: The present case-control study was conducted in an intensive care unit. Failed extubations were used as cases, while successful extubations were used as controls. Extubation failure was defined as reintubation being required within the first 48 hours of extubation.
Results: Out of a total of 956 patients who were admitted to the intensive care unit, 826 were subjected to mechanical ventilation (86%). There were 30 failed extubations and 120 successful extubations. The proportion of failed extubations was 5.32%. The risk factors found for failed extubations were a prolonged length of mechanical ventilation of greater than 7 days (OR = 3.84, 95%CI = 1.01 - 14.56, p = 0.04), time in the intensive care unit (OR = 1.04, 95%CI = 1.00 - 1.09, p = 0.03) and the use of sedatives for longer than 5 days (OR = 4.81, 95%CI = 1.28 - 18.02; p = 0.02).
Conclusion: Pediatric patients on mechanical ventilation were at greater risk of failed extubation if they spent more time in the intensive care unit and if they were subjected to prolonged mechanical ventilation (longer than 7 days) or greater amounts of sedative use.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180477 | PMC |
| http://dx.doi.org/10.5935/0103-507x.20180046 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sarcopenia and frailty in critical illness.
Curr Opin Clin Nutr Metab Care
March 2025
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen.
Purpose Of Review: Sarcopenia and frailty are common conditions, associated with worse clinical outcomes during critical illness. Recent studies on sarcopenia and frailty in ICU patients are presented in this review, aiming to identify accurate diagnostic tools, investigate the effects on clinical and functional outcomes, and propose possible effective interventions.
Recent Findings: The recent change of the sarcopenia definition underlines the importance of muscle strength over mass, this is however challenging to assess in ICU patients.
Reconstruction of hand surgical wounds after pseudo-syndactyly correction or squamous cell carcinoma resection in patients affected from epidermolysis bullosa: a monocentric experience with a collagen-elastin dermal matrix substitute.
Dermatol Reports
February 2025
Division of Regenerative and Oncological Dermatological Surgery, Modena University Hospital.
In patients with epidermolysis bullosa (EB), surgery may be required to remove squamous cell carcinoma (SCC) of the hands or to correct pseudo-syndactyly. Dermal substitutes may represent a suitable tool to promote the healing of surgical wounds in EB. We review our experience with a collagen-elastin dermal matrix to promote surgical wound healing due to hand surgery to correct pseudo-syndactyly or SCC resection in patients affected by EB.
View Article and Find Full Text PDFBreaking the cycle: Addressing the drucebo effect in lymphedema care.
Phlebology
March 2025
Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
The drucebo effect, a lesser-known counterpart to the nocebo effect, arises from negative perceptions specifically related to medical interventions and healthcare settings. This phenomenon can significantly influence the management of lymphedema, a chronic and often debilitating condition characterized by fluid retention and tissue swelling. The drucebo effect not only exacerbates symptom perception but also negatively impacts adherence to therapy and overall patient prognosis.
View Article and Find Full Text PDFImportance: Exercise intervention studies have shown benefits for patients with lung cancer undergoing surgery, yet most interventions to date have been resource intensive and have followed a one-size-fits-all approach.
Objective: To determine whether a personalized, clinic-aligned perioperative exercise program with remote monitoring and instructions can improve physical function and fatigue among patients undergoing surgery for lung cancer.
Design, Setting, And Participants: The Precision-Exercise-Prescription (PEP) randomized clinical trial is a single-center phase 3 trial.
Continuous Kidney Replacement Therapies: Core Curriculum 2025.
Am J Kidney Dis
March 2025
Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Critically ill patients that require kidney replacement therapy (KRT) are among the most ill and complex patients routinely encountered in the intensive care unit (ICU). Continuous KRT (CKRT) is used across many ICUs as the therapy of choice for hemodynamically unstable patients with kidney failure. Though existing trials have not shown superior survival or kidney recovery with CKRT relative to intermittent KRT, CKRT has largely become the standard of care in developed nations for the treatment of acute kidney injury (AKI) in patients with shock, acute brain injury, acute liver failure, and other forms of critical illness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!