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Parkinson's disease screening using a fusion of gait point cloud and silhouette features.
PLoS One
January 2025
Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Parkinson's Disease (PD) is a neurodegenerative disorder that is often accompanied by slowness of movement (bradykinesia) or gradual reduction in the frequency and amplitude of repetitive movement (hypokinesia). There is currently no cure for PD, but early detection and treatment can slow down its progression and lead to better treatment outcomes. Vision-based approaches have been proposed for the early detection of PD using gait.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Cornell University, Ithaca, NY, USA.
Background: Alzheimer's disease (AD) manifests with early spatial memory impairment and is linked to the degeneration of hippocampal circuits. Hippocampal sharp wave ripples (SWRs) are high-frequency population-burst events that coordinate the reactivation of neural assemblies (groups of neurons that become correlated in their firing patterns during learning) in post-learning sleep, which is the neural basis of memory consolidation. SWRs are reduced in the APP/PS1 mouse model of AD-like pathology.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
University of Michigan Medical School, Ann Arbor, MI, USA.
Background: Cognitive changes affecting performance are subtle in early stages of Alzheimer's Disease (AD) and may emerge only with more complex tasks. Driving is a highly challenging instrumental activity of daily living, requiring higher order integration of cognitive skills. For example, driving on freeway entrance ramps requires heightened cognitive engagement such as rapid responses to fast-emerging traffic and sudden speed changes, combining sensory processing and manipulative actions.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Konkuk University School of Medicine, Chungju, Chungbuk-do, Korea, Republic of (South).
Background: The purpose of this study was to compare gait pattern and cognitive function among elderly patients with Alzheimer's Disease (AD), elderly people with Mild Cognitive Impairment (MCI), and Healthy Controls (HC).
Method: Twenty three elderly patients participated: 25 AD (78.4±6.
Clinical Manifestations.
Alzheimers Dement
December 2024
Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Background: Posterior Cortical Atrophy (PCA) is a syndrome characterized by a progressive decline in higher-order visuospatial processing, leading to symptoms such as space perception deficit, simultanagnosia, and object perception impairment. While PCA is primarily known for its impact on visuospatial abilities, recent studies have documented language abnormalities in PCA patients. This study aims to delineate the nature and origin of language impairments in PCA, hypothesizing that language deficits reflect the visuospatial processing impairments of the disease.
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