Usefulness of both PET/CT with F18-FDG and whole-body diffusion-weighted imaging in cancer screening: a preliminary report.

Objective: Positron emission tomography/computed tomography (PET/CT) with fluorodeoxyglucose (F18-FDG) is useful for the detection of malignant lesions, including metastatic lesions, and this technique is widely used in cancer screening. However, this approach may occasionally yield false-positive and false-negative findings. At our PET center, to increase the accuracy of PET/CT, we use PET/CT and whole-body diffusion-weighted imaging (WB-DWI) together. This study aimed to assess the usefulness of this combination.

Methods: We examined 29 subjects with confirmed diagnosis. All of them had undergone PET/CT and WB-DWI on the same day. Twenty-seven of them also underwent ultrasonography, blood testing, and upper gastrointestinal series on the same day and two fecal occult blood tests on another day. WB-DWI was performed on a 1.5-T MRI unit with a b value of 0 and 800 or 1000 s/mm. For all 29 cases, PET/CT and WB-DWI were classified to be positive or negative, and the diagnostic ability was calculated for each modality.

Results: Among the 29 subjects, 17 had malignant tumors and 12 had benign tumors or no abnormalities. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT were 65%, 25%, 55%, 33%, and 48%, respectively; while the corresponding values for WB-DWI were 59%, 100%, 100%, 63%, and 76%, respectively. By considering the result to be negative when PET/CT findings were positive but WB-DWI findings were negative, specificity increased from 25 to 100%, and accuracy increased from 48 to 76%. On the other hand, by considering the result to be positive when the findings of either PET/CT or WB-DWI were positive, sensitivity increased from 65 to 76%, and accuracy increased from 48 to 55%.

Conclusions: Our results suggest that using both PET/CT and WB-DWI together can increase accuracy in cancer screening. However, this approach was not able to detect malignant lesions in some cases, indicating that there were limitations with imaging certain organs. Therefore, it is important to further understand the features of PET/CT and WB-DWI and use them appropriately for each organ. Additionally, given that the study sample was relatively small, further research is needed to validate these findings.