Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents.

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Department of Chemistry, Graduate School of Science and Technology, Kumamoto University, 2-39-1 Kurokami, Chuo-ku, kumamoto, 860-8555, Japan.

Published: October 2018

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Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz)(NHtrz)](BF) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175957PMC
http://dx.doi.org/10.1038/s41598-018-33362-6DOI Listing

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