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Correlation of precisely fabricated geometric characteristics of DNA-origami nanostructures with their cellular entry in human lens epithelial cells.
Discov Nano
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Institute of Medical Research, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, 710072, Shaanxi, China.
Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g.
View Article and Find Full Text PDFAlzheimer's disease (AD) is an age-related neurodegenerative pathology. Brain-derived extracellular vesicles (EVs) have been demonstrated to be implicated in AD pathogenesis by facilitating the propagation of Tau, amyloid-β and inflammatory cytokines. However, the impact of peripheral EVs (pEVs) in AD pathogenesis remains poorly investigated.
View Article and Find Full Text PDFThymoquinone-PLGA-PF68 Nanoparticles Induce S Phase Cell Cycle Arrest and Apoptosis, Leading to the Inhibition of Migration and Colony Formation in Tamoxifen-Resistant Breast Cancer Cells.
Curr Mol Med
January 2025
Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Penang, Malaysia.
Background: A biocompatible polymeric nanoparticle, TQ-PLGA-PF68, was developed through the interaction of the phytochemical thymoquinone (TQ) encapsulated in poly(L-lactide-co-glycolide)-b-poly(ethylene glycol) (PLGA-PEG) with Pluronics F68. So far, this combination has not been assessed on breast cancer cells resistant to anti-cancer drugs. Therefore, this study aimed to assess the cell death caused by TQ-PLGA-PF68 nanoparticles, particularly in resistant breast cancer cell lines expressing estrogen receptor (ER) positivity, such as TamR MCF-7.
View Article and Find Full Text PDFThe transition process of perceptions of hygiene care practices among nurses in acute-care wards: A grounded theory study.
Jpn J Nurs Sci
January 2025
Faculty of Health Sciences, Hokkaido University, Hokkaido, Japan.
Aim: To explore how perceptions of hygiene care practices among nurses in acute-care wards change over their clinical experience.
Methods: Based on symbolic interactionism, we employed a grounded theory methodology to explore interrelationships of meaning arising from actors' perceptions and interactions. Thirty-three nurses working in acute-care wards for >3 years were selected by purposive snowball and theoretical sampling; semi-structured individual interviews were conducted from October 2023 to February 2024.
Challenges of Biological Complexity in the Study of Nanotoxicology.
Chem Res Toxicol
January 2025
Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States.
The scale of nanoparticle use in consumer goods has grown exponentially over several decades owing to the unique properties of materials in this size range. At the same time, well-defined end of life cycle disposal strategies have not been developed for most materials, meaning that we are approaching the potential for a new ecological disaster with the release of millions of metric tons of nanoparticles into the waste stream. The field of nanotoxicology has grown to meet the challenge of investigating the potential hazards of these materials and has already identified toxicity mechanisms that affect multiple tropes of life.
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