AI Article Synopsis
- Lonicera japonica (LJP) is a Chinese herbal medicine studied for its immunomodulatory effects.
- The study involved qualitative analysis using FT-IR and explored its monosaccharide composition through HPLC, revealing it consists of six types of monosaccharides.
- Results indicated that LJP significantly enhanced immune functions in cyclophosphamide-treated mice, boosting spleen lymphocyte activity and restoring key serum cytokines, suggesting its potential as an immunomodulatory agent.
Article Abstract
Lonicera japonica is a typical Chinese herbal medicine. We previously reported a method to isolate polysaccharides from Lonicera japonica (LJP). In this study, we first performed a qualitative analysis of LJP using the Fourier Transform Infrared Spectrometer (FT-IR) and explored the monosaccharide composition of LJP using the pre-column derivatization high performance liquid chromatography (HPLC) method. We then investigated the immunomodulatory function of LJP in cyclophosphamide (CTX)-induced immunosuppressed mouse models. The results showed that LJP had the characteristic absorption of typical polysaccharides consisting of 6 types of monosaccharides. In addition, LJP can increase significantly the organ index, splenic lymphocyte proliferation, macrophage phagocytosis, and natural killer (NK) cell activity in CTX-treated mice. LJP could also restore the levels of serum cytokines interleukin (IL-2), tumor necrosis factor (TNF-α) and Interferon-γ (IFN-γ) in the CTX-treated mice. Finally, the results on measuring the T-lymphocytes subsets of spleen also confirmed LJP-induced immunomodulatory activity in immunosuppressed mice from another perspective. Therefore, LJP could be used as a potential immunomodulatory agent.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175272 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204152 | PLOS |
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