Background: The aberrant immune response in inflammatory bowel disease (IBD) and immunosuppression may intrinsically predispose patients to infectious complications, such as herpes zoster (HZ). We quantified the incidence of HZ in IBD patients in the province of Quebec, Canada.
Methods: We performed a descriptive study using the provincial "Regie de l'Assurance Maladie du Québec" (RAMQ) health registry from 1996 to 2015. The study population consisted of all subjects in the source population who fulfilled the CD and UC case-defining criteria. HZ incidence rates (IRs) in person-years (py) were calculated according to age groups, sex, Charlson Comorbidity index (CCI), and IBD type. Age standardized incidence ratios (SIRs) were performed using the Quebec general population as reference.
Results: A total of 39,366 patients met the diagnostic criteria of either Crohn's disease (CD; n = 23,388), ulcerative colitis (UC; n = 14,513), or IBD unclassified (n = 1465). We identified 2158 HZ cases. Crude IR was 6.67 cases/1000 py and 7.22 cases/1000 py for CD and UC patients, respectively. Unclassified IBD crude HZ IR was 7.54 cases/1000 py. No significant time trend was identified. HZ incidence is high in IBD patients >50 years of age and among the very young (0-17 years of age; SIR, 3.38; 95% confidence interval, 2.64-4.26), especially females.
Conclusions: These data suggest that HZ incidence is high in the IBD population. Preventives measures should be implemented in this at-risk population.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1093/ibd/izy311 | DOI Listing |
Otol Neurotol Open
December 2024
Department of Head and Neck Surgery, Los Angeles, California.
Objectives: Ramsay Hunt syndrome (RHS) refers to a reactivation of the varicella-zoster virus in the distribution of the facial nerve, but it can involve other cranial nerves as well. In patients with polyneuropathy, the vestibulocochlear nerve is most involved after the facial nerve. The clinical manifestations and long-term vestibular outcomes in these patients remain unclear.
View Article and Find Full Text PDFVaccine
December 2024
F.I. Proctor Foundation, University of California, San Francisco, California, United States; Department of Ophthalmology, University of California, San Francisco, California, United States; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, United States. Electronic address:
Background: Herpes zoster is a potential risk factor for dementia. The effectiveness of the recombinant zoster vaccine for preventing dementia is uncertain.
Methods: This retrospective cohort study used de-identified claims data from the Optum Labs Data Warehouse database from January 1, 2017, to December 31, 2022, to determine whether the recombinant zoster vaccine is associated with a reduced risk of dementia.
Med Sci Monit
December 2024
Department of Neurology, HangZhou Third People's Hospital, Hangzhou, Zhejiang, China.
BACKGROUND This study aimed to analyze the risk factors of central nervous system (CNS) infection caused by reactivation of varicella zoster virus (VZV) and provide reference for the prevention and early diagnosis of VZV-associated CNS infection. MATERIAL AND METHODS A prospective study was conducted on 1030 patients with acute herpes zoster (HZ) admitted to our hospital from January 2021 to June 2023. According to clinical manifestations and auxiliary examinations, they were divided into HZ group of 990 patients and VZV-associated CNS infection group of 40 patients.
View Article and Find Full Text PDFClin Pract
December 2024
Department of Gynecology and Obstetrics, University Hospital, Philipps-University Marburg, Baldingerstraße, 35043 Marburg, Germany.
Purpose: The purpose of this study was to investigate a possible association between Herpes Zoster (HZ) and the subsequent diagnosis of breast cancer (BC).
Methods: Utilizing the Disease Analyzer database, anonymized medical records from German office-based practices were accessed. Longitudinal data of female patients aged 18 years and above diagnosed with HZ between 2005 and 2021 were included.
Clin Microbiol Infect
December 2024
Department of Infectious Diseases, Aalborg University Hospital, 9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, 9000 Aalborg, Denmark; European Society of Clinical Microbiology and Infectious Diseases Study Group of Infections of the Brain (ESGIB).
Background: Infectious encephalitis poses a global health challenge with a high mortality and severe neurological consequences in survivors. Emerging pathogens and outbreaks are reshaping the patterns of the disease.
Objective: To understand the current epidemiology for improving prevention, diagnosis, and treatment.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!