AI Article Synopsis
- - A novel peroxy fatty acid named tagetnoic acid and four known metabolites were isolated from the aerial parts of a plant in the Asteraceae family, and their structures were confirmed through various analytical techniques.
- - These compounds showed strong lipoxygenase inhibitory activity with IC values indicating effectiveness compared to the standard drug indomethacin.
- - The study suggests that consuming these compounds might benefit individuals at risk for inflammatory disorders due to their potential anti-inflammatory properties.
Article Abstract
A new peroxy fatty acid, tagetnoic acid () [4-((3,6)-6-((3,8)-octadeca-3,8-dien-1-yl)-3,6-dihydro-1,2-dioxin-3-yl)butanoic acid] and four known metabolites: ecliptal (5-formyl--terthiophene) (), 5-(4-hydroxybut-1-ynyl)-2,2'-bithiophene (), 22,23-dihydrospinasterone (), and stigmasterol () were separated from the -hexane fraction of the aerial parts of L. (Asteraceae). Their chemical structures were verified using IR, UV, 2D and 1D NMR, and HRMS. Compounds displayed potent lipoxygenase inhibitory potential with ICs 2.26, 1.83, and 1.17 μM, respectively compared to indomethacin (IC 0.89 μM). Moreover, molecular docking study revealed that the potent activity of is due to H-bonding and hydrophobic interaction. The results of this study suggested that dietary consumption would be useful for the individuals at risk of acute and chronic inflammatory disorders.
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| http://dx.doi.org/10.1080/14786419.2018.1488712 | DOI Listing |
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Tagetnoic acid, a new lipoxygenase inhibitor peroxy fatty acid from growing in Saudi Arabia.
Nat Prod Res
February 2020
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Article Synopsis
- - A novel peroxy fatty acid named tagetnoic acid and four known metabolites were isolated from the aerial parts of a plant in the Asteraceae family, and their structures were confirmed through various analytical techniques.
- - These compounds showed strong lipoxygenase inhibitory activity with IC values indicating effectiveness compared to the standard drug indomethacin.
- - The study suggests that consuming these compounds might benefit individuals at risk for inflammatory disorders due to their potential anti-inflammatory properties.
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