Detailed computational (DFT) studies of the palladium(II)-catalyzed Claisen rearrangement of 2-allyloxy- and propargyloxyindoles revealed an unexpected divergent mode of reactivity. Subsequent experimental kinetic isotope effects are in accord with the mechanism derived from the computations. The computational results led to the development of Pd(II)-catalyzed [3,3]-sigmatropic rearrangement of 3-aryl substituted 2-propargylindoles.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201310 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.8b02864 | DOI Listing |
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