AI Article Synopsis
- The study aimed to explore how acute graft-versus-host disease (aGVHD) relates to the types of cells in transplants for patients with aplastic anemia after receiving stem cell transplants from partially matched donors.
- The researchers analyzed 57 patients, categorizing them into two groups based on the presence or absence of grade II-IV aGVHD, and compared their graft cell compositions.
- Findings showed that while most cell types were similar between both groups, those with grade II-IV aGVHD had significantly lower CD34 cell counts than those without, suggesting a link between lower CD34 counts and a higher risk of aGVHD.
Article Abstract
Objective: To investigate the relationship between acute graft-versus-host disease and graft composition in patients with aplastic anemia(AA) after haploidentical hematopoietic stem cell transplantation.
Methods: Fifty-seven cases of AA after haploidentical hematopoietic stem cell transplantation were retrospectively analyzed. All the patients were divided into 2 groups according to whether presence or absence grade Ⅱ-Ⅳ aGVHD, the relationship between aGVHD and graft composition was analyzed by comparing the differences of graft components between the 2 groups.
Results: Fourteen out of 57 patients had grade Ⅱ-Ⅳ aGVHD and the other 43 did not have grade Ⅱ-Ⅳ aGVHD. The mononuclear cells, CD3, CD4, CD8, NK cells, NKT cells, B cells and Treg cells were not significantly different between the 2 groups (P>0.05), the CD34 cell count in the patients with grade Ⅱ-Ⅳ aGVHD was 3.85（1.73-10.61）×10/kg, which was significantly lower than that without grade Ⅱ-ⅣaGVHD: 6.31（2.98-19.35）×10/kg (P<0.05).
Conclusions: The incidence of grade Ⅱ-Ⅳ aGVHD may be related with CD34 cell count in AA after haploidentical hematopoietic stem cell transplantation..
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| http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.031 | DOI Listing |
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