Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with a wide range of clinical presentations, from asymptomatic or mildly ill to severe respiratory illness including death. We describe isolation of infectious MERS-CoV from the upper respiratory tract of a mildly ill 27-year-old female in Saudi Arabia 15 days after illness onset.
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http://dx.doi.org/10.1093/ofid/ofy111 | DOI Listing |
PLoS One
December 2024
National Institute for Public Health and the Environment (RIVM), Centre for Infectious Diseases Research, Diagnostics and Laboratory Surveillance, Bilthoven, NLD.
At the beginning of the COVID-19 pandemic, diagnostic testing was not accessible for mildly ill or asymptomatic individuals. Military operational circumstances exclude the usage of reference laboratory tests. For that reason, at the beginning of the pandemic alternative test methods were needed in order to gain insight into the SARS-CoV-2 status of military personnel.
View Article and Find Full Text PDFmBio
November 2024
Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA.
The mechanisms controlling (Mtb) replication and survival inside its human host remain ill-defined. Phagosome acidification and nutrient deprivation are common mechanisms used by macrophages to restrict the replication of intracellular bacteria. Mtb stops replicating at mildly acidic pH (
J Psychosom Res
January 2025
School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Epilepsy Behav
October 2023
Department of Medicine, Tiradentes University, Aracaju, Sergipe, Brazil.
Seizures may be one of the neurological consequences of COVID-19. The present study aims to review the prevalence of seizures in COVID-19 patients considering sex and geographical origin. A review protocol was submitted to the PROSPERO database (CRD42021281467).
View Article and Find Full Text PDFPharmacol Res Perspect
October 2024
Grand Medical Pty Ltd, St Leonards, New South Wales, Australia.
Increased circulating histones correlate with sepsis severity and are a potential therapeutic target. Pre-clinical studies showed benefit with a histone-neutralizing polyanion molecule (STC3141). We aimed to investigate the safety, tolerability, and pharmacokinetics of STC3141 in critically ill patients with sepsis.
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