Background: Osteopontin () is one of the co-factors involved in cell adhesion and invasion during the implantation process. Several reports have shown expression changes in diabetic condition in several tissues. In addition, an increased incidence of spontaneous abortion is reported in diabetic women. We, therefore, designed a study to evaluate the effects of diabetes on expression at implantation time after treatment with metformin and pioglitazone.
Materials And Methods: In this interventional and experimental study, 28 rats were randomly divided into four groups, namely control, diabetic, pioglitazone-treated diabetic rats and metformin-treated diabetic rats. Streptozotocin (STZ) and nicotinamide (NA) were used to induce type 2 diabetes (T2D). During the implantation window, the endometrium was removed and the expression of was analysed by reverse transcription quantitative polymerase chain reaction (RT-qPCR).
Results: expression was significantly higher (30.70 fold-changes) in the diabetic group in comparison with the control group (P=0.04). Furthermore, the expression of was significantly lower in the diabetic group treated with pioglitazone when compared with the diabetic group (P=0.04).
Conclusion: According to the high expression and the possibility of increased adhesion of endometrial epithelial cells, the invasion of blastocyst may be affected and thus reduced. As pioglitazone significantly reversed the upregulation of in diabetic rats, it may be considered as a therapeutic compound for treating T2D.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186281 | PMC |
http://dx.doi.org/10.22074/ijfs.2019.5471 | DOI Listing |
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