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| http://dx.doi.org/10.1016/j.bpj.2018.09.012 | DOI Listing |
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Diagnostic Sensitivity of Abdominal Fat Aspiration Biopsy for Cardiac Amyloidosis: A Systematic Review and Meta-Analysis.
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April 2024
Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.
Cardiac amyloidosis is a lethal disease, the incidence of which is increasing every year. Early diagnosis and treatment are the keys to reducing the mortality of this disease. Relevant English literature published in Embase, PubMed, Cochrane Library, and Web of Science were searched until December 1, 2022.
View Article and Find Full Text PDFUnlocking Modifiable Risk Factors for Alzheimer's Disease: Does the Oral Microbiome Hold Some of the Keys?
J Alzheimers Dis
April 2023
Deakin University, IPAN - the Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, VIC, Australia.
Advancing age is recognized as the primary risk factor for Alzheimer's disease (AD); however approximately one third of dementia cases are attributable to modifiable risk factors such as hypertension, diabetes, smoking, and obesity. Recent research also implicates oral health and the oral microbiome in AD risk and pathophysiology. The oral microbiome contributes to the cerebrovascular and neurodegenerative pathology of AD via the inflammatory, vascular, neurotoxic, and oxidative stress pathways of known modifiable risk factors.
View Article and Find Full Text PDFCerebral amyloid angiopathy with focal presentation-about 3 cases.
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Institut du Vieillissement I-Vie, Hospices Civils de Lyon, 27 rue Gabriel Péri, 69100, Villeurbanne, France.
Cerebral amyloid angiopathy (CAA) is a common cerebrovascular disease involved in ischemic and hemorrhagic strokes, and its progression is correlated to cognitive decline. In vivo diagnosis of CAA is guided by the modified Boston criteria, with the presence of multiple intracerebral hemorrhage or cerebral microbleeds (CMB), or single hemorrhage and cortical superficial siderosis. The diagnosis of CAA is highly dependent on the quality of imaging and the advent of susceptibility-weighted imaging (SWI) sequences has improved sensitivity of MRI to detect hemosiderin deposition and CMB, hallmarks of CAA.
View Article and Find Full Text PDFKeys to early diagnosis of cardiac amyloidosis: red flags from clinical, laboratory and imaging findings.
Eur J Prev Cardiol
November 2020
Institute of Life Sciences, Scuola Superiore Sant'Anna, Italy.
Cardiac involvement in systemic amyloidosis, due either to immunoglobulin light-chain or transthyretin amyloidosis, influences clinical presentation and is a strong predictor of unfavourable outcome. Until recently considered as a rare, incurable disease, cardiac amyloidosis, is still mis/underdiagnosed, although treatments effective in improving patient survival are now available for both subtypes, including chemotherapy regimens for immunoglobulin light-chain amyloidosis and tetramer stabiliser for transthyretin amyloidosis. Achieving a timely diagnosis allows initiating life-saving therapies and requires the early recognition of clinical, laboratory and imaging signs of cardiac involvement, some of them may be apparent well before the disease becomes clinically manifest.
View Article and Find Full Text PDFDiagnosis and treatment of urinary and sexual dysfunction in hereditary TTR amyloidosis.
Clin Auton Res
September 2019
Department of Urology, University of Rennes, Service d'Urologie, 2 Rue Henri Le Guilloux, 35000, Rennes, France.
Purpose: We aimed to review the current knowledge on the epidemiology, diagnosis, and management of urinary and sexual dysfunction in patients with TTR amyloidosis (ATTR).
Methods: We performed a review of the literature, screening for randomized controlled trials, prospective and retrospective series, position papers, and guidelines on urinary and sexual dysfunction in ATTR patients published in PubMed and Embase.
Results: Lower urinary tract dysfunction is present in up to 83% of patients with ATTR.
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