We present a case of possible olanzapine-induced rhabdomyolysis in the absence of other features of neuroleptic malignant syndrome (NMS). There is evidence to suggest that there are different underlying pathophysiological mechanisms for rhabdomyolysis occurring alone, in contrast to when it presents as part of NMS. This has possible implications for drug rechallenge which is discussed.
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Delayed-Onset olanzapine-induced rhabdomyolysis.
BMJ Case Rep
March 2023
General Medicine, The Northern Hospital, Epping, Victoria, Australia.
Olanzapine is a commonly used and effective second-generation antipsychotic agent used for the control of paranoia and agitation in schizophrenia and bipolar disorder as well as in the behavioural and psychological symptoms of dementia. Serious side effects of treatment are uncommon but spontaneous rhabdomyolysis represents a rare complication. We describe here a patient treated with a stable dose of olanzapine for more than 8 years who developed acute severe rhabdomyolysis without an identifiable trigger and without features suggestive of neuroleptic malignant syndrome.
View Article and Find Full Text PDFOlanzapine induced hyponatremia and rhabdomyolysis.
Clin Case Rep
February 2023
Emergency Department, IBN SINA Hospital, Faculty of Medicine and Pharmacy University Mohammed V Rabat Morocco.
Rapid-onset hyponatremia and rhabdomyolysis are rare, but potential, complications of olanzapine treatment. Hyponatremia, secondary to atypical antipsychotic use, has been reported in many case reports and is thought to be associated with an inappropriate antidiuretic hormone secretion syndrome. We report a case of sudden-onset hyponatremia associated with a severe rhabdomyolysis resulting in a coma-necessitating intensive care unit admission.
View Article and Find Full Text PDFDelayed olanzapine induced myocarditis and rhabdomyolysis.
Postgrad Med J
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Department of Cardiology, Imperial College Healthcare NHS Trust, London, UK.
Olanzapine-induced diabetic ketoacidosis and neuroleptic malignant syndrome with rhabdomyolysis: a case report.
Endocrinol Metab (Seoul)
March 2013
Division of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea.
Atypical antipsychotics have replaced conventional antipsychotics in the treatment of schizophrenia because they have less of a propensity to cause undesirable neurologic adverse events including extrapyramidal symptoms, tardive dyskinesia, and neuroleptic malignant syndrome (NMS). However, atypical antipsychotics have been known to result in various metabolic complications such as impaired glucose tolerance, diabetes and even diabetic ketoacidosis (DKA). In addition, a number of NMS cases have been reported in patients treated with atypical antipsychotics, although the absolute incidence of neurologic side effects is currently significantly low.
View Article and Find Full Text PDF[Olanzapine induced rhabdomyolysis and serum creatine kinase increase].
Rev Med Interne
June 2009
Département de médecine générale, faculté de médecine Jacques-Lisfranc, université Jean-Monnet, 42023 Saint-Etienne cedex 2, France.
Introduction: "Atypical" antipsychotics tend to replace traditional antipsychotics as first line therapy for psychotic disorders, due to their better side-effect profile with fewer extrapyramidal manifestations, allowing a better observance. Nevertheless, second-generation antipsychotics may also lead to adverse events such as metabolic disorders, agranulocytosis or muscle damage. Cases of rhabdomyolysis (aside neuroleptic malignant syndrome) have been reported in patients receiving olanzapine (Zyprexa).
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