Molecular docking, and anti-biofilm activity of gold-complexed sulfonamides on Pseudomonas aeruginosa.

The antibacterial activity of sulfadiazine Au-PPh, sulfadiazine PhP-Au-Au-PPh, sulfamethoxazole Au-PPh, sulfamethoxazole PhP-Au-Au-PPh, sulfamethoxazole Au-PPh were tested against Pseudomonas aeruginosa. The antibacterial activity of sulfonamide was tested against P. aeruginosa through the MIC assay, quantitative analysis of biofilm inhibition and observation of biofilm formation with fluorescence microscopy. Besides, the compounds presented remarkable inhibition of P. aeruginosa biofilm formation. Furthermore, molecular docking was performed to identify the key structural features of these compounds with the binding site of the LasR receptor.