Taking on the Elephant in the Tissue Culture Room: iPSC Modeling for Sporadic ALS.

Modeling ALS remains a major challenge since the vast majority of cases are sporadic. Recently in Nature Medicine, Fujimori et al. leverage genetic heterogeneity and define subgroups of iPSC-derived motor neurons using multiplex phenotypic profiles, and thus make substantial progress toward robust modeling of both familial and sporadic ALS.