Herein, we reported a successful Suzuki-Miyaura coupling of dimethyl aryl amines to forge biaryl skeleton via Ni catalysis in the absence of directing groups and preactivation. This transformation proceeded with high efficiency in the presence of magnesium. Preliminary mechanism studies demonstrated dual roles of magnesium: (i) a reductant that reduced Ni(II) species to active Ni(I) catalyst; (ii) a unique promoter that facilitated the Ni(I)/Ni(III) catalytic cycle.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/jacs.8b08779 | DOI Listing |
Publication Analysis
Top Keywords
dimethyl aryl
8
aryl amines
8
ni-catalyzed cross-coupling
4
cross-coupling dimethyl
4
amines arylboronic
4
arylboronic esters
4
esters reductive
4
reductive conditions
4
conditions reported
4
reported successful
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!