The purpose of this study was to develop a comprehensive understanding of temper outbursts in Prader-Willi syndrome (PWS). A survey was developed from interviews conducted with individuals with PWS and their caregivers. The survey was completed by 101 primary caregivers. The findings suggest that outburst frequency decreases with age while duration increases. Adolescents exhibited more severe behaviors than children or adults. No differences were found across gender or genetic subtype. Provocations fit into three themes: goal blockage, social injustice, and difficulty dealing with change. Distracting the person or giving them space to calm down were the only management strategies judged effective. Risperidone, sertraline, and fluoxetine were the most common medications prescribed for outbursts, though parents reported only minor effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ajmg.a.40480 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Network structure of phasic and tonic irritability in adults: A Bayesian Gaussian graphical model.
J Affect Disord
December 2024
Department of Psychological & Brain Sciences, Boston University, Boston, MA, USA. Electronic address:
Background: Tonic (i.e., irritable mood) and phasic (i.
View Article and Find Full Text PDFThe relationship between cardiac activity, behaviour and endogenous oxytocin and vasopressin in Prader-Willi Syndrome: An exploratory study.
Int J Psychophysiol
November 2024
Faculty of Medicine and Health, Brain and Mind Centre, The University of Sydney, New South Wales, Australia.
This study aimed to increase our understanding of cardiac activity abnormalities in Prader-Willi Syndrome (PWS) and the relationship between cardiac activity, PWS behaviours thought to be associated with cardiac vagal tone and endogenous oxytocin and vasopressin levels. We compared cardiac activity (respiratory sinus arrhythmia (RSA), low-frequency heart rate variability (LF-HRV), heart period) in 30 adolescents and adults with PWS to 30 typically developing age-matched controls. RSA, LF-HRV, and heart period were lower in individuals with PWS than in the control group.
View Article and Find Full Text PDFTranscutaneous auricular vagus nerve stimulation to acutely reduce emotional vulnerability and improve emotional regulation in borderline personality disorder (tVNS-BPD): study protocol for a randomized, single-blind, sham-controlled trial.
Trials
June 2024
Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Background: Borderline personality disorder (BPD) is considered a disorder of emotion regulation resulting from the expression of a biologically determined emotional vulnerability (that is, heightened sensitivity to emotion, increased emotional intensity/reactivity, and a slow return to emotional baseline) combined with exposure to invalidating environments. Vagal tone has been associated with activity in cortical regions involved in emotion regulation and a lower resting state of vagal tone has been observed in BPD patients relative to healthy controls. Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has been shown to reduce temper outbursts in adults with Prader-Willi Syndrome, to enhance recognition of emotions in healthy students, and to improve depressive and anxiety symptoms.
View Article and Find Full Text PDFThe Affective Side of Disruptive Behavior: Toward Better Understanding, Assessment, and Treatment.
J Clin Child Adolesc Psychol
April 2024
Department of Psychological Sciences, University of Connecticut.
Historically, much of the progress made in youth mental health research can be classified as focusing on , characterized by disruptive behavior (e.g. aggression, defiance), or , characterized by intense negative affect (e.
View Article and Find Full Text PDFDifferential DNA methylation in iPSC-derived dopaminergic neurons: a step forward on the role of SNORD116 microdeletion in the pathophysiology of addictive behavior in Prader-Willi syndrome.
Mol Psychiatry
September 2024
Centre de Référence National du Syndrome de Prader-Willi et Syndromes avec Troubles du Comportement Alimentaire, Unité d'Endocrinologie, Hôpital des Enfants, Institut des Handicaps Neurologiques, Psychiatriques et Sensoriels, CHU de Toulouse; Infinity Center, Inserm CNRS UMR1291, University of Toulouse 3 Paul Sabatier, Toulouse, France.
Article Synopsis
- A microdeletion involving the SNORD116 gene is linked to Prader-Willi syndrome (PWS), which presents with symptoms like intellectual disability, emotional dysregulation, and food-related behaviors resembling addiction.
- The study investigates DNA methylation and gene expression differences in dopaminergic neurons from individuals with the SNORD116 microdeletion compared to healthy controls, also examining the influence of oxytocin (OXT).
- Findings reveal over 153,000 differentially methylated cytosines, with changes in genes related to the dopaminergic system, including hypermethylation and under-expression of COMT and hypomethylation and over-expression of SLC6A3 in neurons with SNORD116 MD.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!