AI Article Synopsis
- The study aimed to evaluate the blood sugar-lowering effects of the aqueous extract from the aerial parts of Mentha pulegium (M. pulegium) in both normal and diabetic rats.
- The extract (20 mg/kg) significantly reduced blood glucose levels in STZ-induced diabetic rats and improved glucose tolerance in normal rats, with beneficial changes observed in liver and pancreas tissues.
- Preliminary phytochemical analysis revealed the presence of various bioactive compounds, suggesting that M. pulegium could be a potential natural treatment for managing diabetes.
Article Abstract
Objective: The aim of this work was to evaluate the antihyperglycemic activity of aerial parts aqueous extract (A.P.A.E) of Mentha pulegium (M. pulegium) on blood glucose levels in normal and streptozotocin(STZ)-induced diabetic rat. The glucose tolerance was evaluated in normal rats. Moreover, the histological sections and morphometric analysis at the liver and pancreas have been carried out in this investigation both in normal and STZ-diabetic rats.
Methods: The effect of A.P.A.E of M. pulegium (20 mg/kg) on blood glucose levels was investigated in normal and diabetic rats (n=6). Histopathological changes in liver and pancreas were examined under phase contrast microscope and a preliminary screening for various bioactive constituents was realized according to standard methods.
Key Findings: Both single and repeated oral administration of A.P.A.E (20 mg/kg) caused a significant reduction in blood glucose levels in STZ-diabetic rats (p<0.0001). The morphometric analysis and histological sections realized in pancreas and liver have showed the beneficial effect of the A.P.A.E in cellular population. According to oral glucose tolerance test (OGTT), the aqueous extract has revealed an improvement of glucose tolerance in normal rat. Furthermore, the preliminary phytochemical screening of A.P.A.E of M. pulegium has demonstrated the presence of various metabolite compounds including polyphenols, flavonoids, terpenoids tannins, cyanidins, sesquiterpenes, and glycosides.
Conclusion: We conclude that the A.P.A.E of M. pulegium (20 mg/kg) exhibits a potent antihyperglycemic activity in STZ diabetic rats.
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| http://dx.doi.org/10.2174/1871530318666181005102247 | DOI Listing |
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