Mathematical biology involves the use of mathematical models derived from biological data to predict the course or outcome of a biological event. In oncology, mathematics plays a vital role in determining the tumor behavior and the optimal treatment strategy including the right combination of treatment modality to be used, and the timing and duration of the treatment. The major limiting factor in mathematical oncology is the inability to obtain accurate biological data to formulate appropriate mathematical models. Development of molecular biology has enabled us to overcome these limitations.
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Symmetry Breaking: Case Studies with Organic Cage-Racemates.
Acc Chem Res
January 2025
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
ConspectusSymmetry is a pervasive phenomenon spanning diverse fields, from art and architecture to mathematics and science. In the scientific realms, symmetry reveals fundamental laws, while symmetry breaking─the collapse of certain symmetry─is the underlying cause of phenomena. Research on symmetry and symmetry breaking consistently provides valuable insights across disciplines, from parity violation in physics to the origin of homochirality in biology.
View Article and Find Full Text PDFThe potential of and bacteriocins in synergistic control of .
Prep Biochem Biotechnol
January 2025
Department of Biology, College of Natural and Mathematical Sciences, University of Dodoma, Dodoma, Tanzania.
has developed resistance to most conventional antibiotics and is a causative agent of serious infections. Alternative therapies are urgently needed. Bacteriocins are ribosomally synthesized antimicrobial peptides produced by bacteria, including () and (), and represent a potential solution.
View Article and Find Full Text PDFBiochemical mechanisms and molecular interactions of vitamins in cancer therapy.
Cancer Pathog Ther
January 2025
Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
Recently, the potential role of vitamins in cancer therapy has attracted considerable research attention. However, the reported findings are inconsistent, with limited information on the biochemical and molecular interactions of different vitamins in various cancer cells. Importantly, the presence of vitamin receptors in tumor cells suggests that vitamins play a significant role in the molecular and biochemical interactions in cancers.
View Article and Find Full Text PDFThe fungal microbiota modulate neonatal oxygen-induced lung injury.
Microbiome
January 2025
Division of Neonatology, Department of Pediatrics, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, AL, USA.
Background: The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity of prematurity. While the microbiota significantly influences neonatal health, the relationship between the intestinal microbiome, particularly micro-eukaryotic members such as fungi and yeast, and lung injury severity in newborns remains unknown.
Results: Here, we show that the fungal microbiota modulates hyperoxia-induced lung injury severity in very low birth weight premature infants and preclinical pseudohumanized and altered fungal colonization mouse models.
A new method for detecting mixed Mycobacterium tuberculosis infection and reconstructing constituent strains provides insights into transmission.
Genome Med
January 2025
Department of Epidemiology of Microbial Disease, Yale School of Public Health, 60 College Street, New Haven, CT, USA.
Background: Mixed infection with multiple strains of the same pathogen in a single host can present clinical and analytical challenges. Whole genome sequence (WGS) data can identify signals of multiple strains in samples, though the precision of previous methods can be improved. Here, we present MixInfect2, a new tool to accurately detect mixed samples from Mycobacterium tuberculosis short-read WGS data.
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