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Methacrylated hyaluronic acid/laponite photosensitive, sustained-release hydrogel loaded with bilobalide for enhancing random flap survival through mitigation of endoplasmic reticulum stress.
Int J Biol Macromol
November 2024
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, PR China; The Second School of Medicine of Wenzhou Medical University, Wenzhou 325000, PR China; Key Laboratory of Orthopaedics of Zhejiang Province, Wenzhou 325000, PR China. Electronic address:
Random flaps are extensively utilized in plastic surgery due to their flexibility compared to traditional axial vascular system arrangements and their resemblance to injured skin in color, thickness, and texture. Despite these advantages, they are susceptible to ischemia-reperfusion injuries and subsequent necrosis post-transplantation. Bilobalide (BB), a sesquiterpene compound derived from Ginkgo biloba, exhibits notable antioxidant and anti-inflammatory properties and is commonly used to treat ischemiareperfusion injuries.
View Article and Find Full Text PDFGingko flap: The development of a novel flap technique to reduce dog ear formation.
J Plast Reconstr Aesthet Surg
January 2019
Dermatology, Oita Medical Association's Almeida Memorial Hospital, 1509-2, Miyazaki, Oita 870-1195, Japan. Electronic address:
Effect of Ginkgo biloba extract (GbE-761) on the survival of fasciocutaneous flaps in rats.
Phytother Res
February 2012
Department of Orthopedics and Traumatology, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de São Paulo, Faculty of Medical Sciences, São Paulo, SP, Brazil.
Cutaneous and fasciocutaneous flaps are used widely in the surgical reconstruction of various body segments, especially to cover exposed vital tissues. Partial or total necrosis of these flaps, secondary to insufficient tissue irrigation, is one possible complication. Therefore, investigations into antiplatelet aggregation, vasodilation and antioxidant properties are highly significant.
View Article and Find Full Text PDF[Extended nasal reconstruction with forehead flap. Report of a series of 12 adults].
Ann Chir Plast Esthet
December 2001
Service de chirurgie plastique, reconstructrice et esthétique, centre des brûlés, hôpital Roger Salengro, CHRU de Lille, boulevard du professeur Jules Leclercq, 59037 Lille, France.
The authors report a study about 12 cases of partial, total and extensive rhinectomy treated by a median "gingko flower" forehead flap. Technical adaptations are described to resolve the difficult problem of support and lining reconstruction. The authors compare their technique with the various other methods: the classical one (Converse scalping and sea-gull Millard's flaps) or more recent surgical solutions (distal composite flaps and expansion).
View Article and Find Full Text PDFThe effect of Gingko biloba extract (Egb 761) as a free radical scavenger on the survival of skin flaps in rats. A comparative study.
Scand J Plast Reconstr Surg Hand Surg
June 1998
Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Yüzüncü Yil University, Van, Turkey.
Free radicals may have a role in pedicle flap necrosis. We undertook this study to compare the effect of various antioxidants and scavengers of free radicals such as vitamin E, vitamin C, deferoxamine, and Gingko biloba extract (Egb 761) on McFarlane caudal-based dorsal rat flaps. Fifty rats were divided into five groups of 10 animals each.
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