Background And Purpose: magnetic resonance enterography has been increasingly used for the diagnosis and follow-up of Crohn's disease (CD). The purpose of the study was to compare the apparent diffusion coefficient (ADC) with wall enhancement for the differentiation of severe, moderate or no inflammation activity in the ileum.
Methods: a prospective, blinded study was conducted of 46 CD patients with a clinical Crohn's disease activity index (CDAI) ≥ 220 and a simple endoscopic score for Crohn's disease (ES-CD) ≥ 7, which yielded 58 inflamed segments with CD. Twenty controls were also included. All segments were characterized by four ADC readings. The two different enhancement patterns observed in inflamed segments, transmural or mucosal, were associated with severely (23) or moderately (35) active CD.
Results: the ADC value decreased from 2.79 ± 0.35 x 10-3 mm2/s for normal segments to 1.81 ± 0.39 x 10-3 mm2/s for the moderately inflamed segments and 1.15 ± 0.20 x 10-3 mm2/s for severely inflamed segments (p ≤ 0.0001). ROC curve analysis on the basis of the three ADC distributions showed a very good discrimination capability with an area under the curve of 0.95. Three groups were defined as follows: normal ileum ADC > 2.4 x 10-3 mm2/s, moderate stages of inflammation 1.5 x 10-3 mm2/s < ADC ≤ 2.4 x 10-3 mm2/s and severe stages of ADC ≤ 1.5 x 10-3 mm2/s.
Conclusions: the ADC value reliably discriminates between normal and inflamed ileum and also distinguishes between severe and moderate inflammation.
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http://dx.doi.org/10.17235/reed.2018.5691/2018 | DOI Listing |
Acta Radiol
January 2025
Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University of College of Medicine, Seoul, Republic of Korea.
Background: In children and young adults, tumors in the chest and thoracic wall exhibit a wide variety of types, making it challenging to differentiate between benign and malignant cases before invasive histopathological examination.
Purpose: To evaluate the utility of apparent diffusion coefficient (ADC) for discriminating malignant thoracic masses in children and young adults.
Material And Methods: This retrospective study included chest magnetic resonance imaging (MRI) scans in patients aged <30 years.
Prostate
March 2025
Department of Radiation Oncology, Baskent University Faculty of Medicine, Ankara, Turkey.
Br J Radiol
November 2024
Department of Plastic and Reconstructive Surgery, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea.
Clin Otolaryngol
November 2024
Department of Otolaryngology, Christian Medical College, Vellore, India.
Mult Scler Relat Disord
November 2024
Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan.
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