It is the data of literature on existing classifications and systems of assessment and prognosis of hepatocellular carcinoma (HCC). In some classifications takes into account only the characteristics of the tumor tissue, in others are used biochemical and clinical characteristics in addition. Some systems allow to predict the survival of patients regardless of the stage of the disease, while others are most effective for the individual stages. The international TNM classification is generally accepted for the development of treatment methods and determining the forecast mainly for resectable HCC forms. The Japanese staging system (JIS) is mainly recommended for operable patients. Italian scale (CLIP), on the contrary, is intended to analyze HCC, which is not subject to surgical treatment. The Barcelona classification of liver cancer (BCLC) is considered the most universal, because it takes into account the stage of disease, the condition of the liver parenchyma and does not depend on the method of treatment and the patient’s place of residence. Therefore, the choice of staging system and assessment of disease prognosis should be based on the clinical and morphological features of the disease, taking into account features of application of various scales.
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Clin Oral Investig
January 2025
Department of Biology, Science Faculty, Atatürk University, Erzurum, Türkiye.
Introduction: Cymbopogon martini, Syzygium aromaticum, and Cupressus sempervirens are used for antimicrobial purposes in the worldwide. Both their extracts and essential oil contents are rich in active ingredients.
Objective: The aim of this study was to investigate the inhibitory effect of Cymbopogon martini essential oil (CMEO), Syzygium aromaticum essential oil (SAEO) and Cupressus sempervirens essential oil (CSEO) on Candida albicans biofilm formation on heat-polymerized polymethyl methacrylate (PMMA) samples in vitro and in silico.
J Health Organ Manag
January 2025
School of Health and Life Sciences, Teesside University, Middlesbrough, UK.
Purpose: The primary purpose of the study was to explore the impact of health workers' awareness of artificial intelligence (AI) on their workplace well-being, addressing a critical gap in the literature. By examining this relationship through the lens of the Job demands-resources (JD-R) model, the study aimed to provide insights into how health workers' perceptions of AI integration in their jobs and careers could influence their informal learning behaviour and, consequently, their overall well-being in the workplace. The study's findings could inform strategies for supporting healthcare workers during technological transformations.
View Article and Find Full Text PDFMed Mycol
January 2025
Fungal Infection Working Group, International Society of Antimicrobial Chemotherapy.
Invasive mould disease (IMD) has a high mortality in immunosuppressed patients. Invasive aspergillosis (IA) is the most common IMD. A guideline for preventing IA has been published jointly by the Centers for Diseases Control and Prevention, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation.
View Article and Find Full Text PDFEur J Cancer
January 2025
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital of Psychiatry II, Medical University of Innsbruck, Innsbruck, Austria. Electronic address:
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Utility - Core 10 Dimensions (QLU-C10D) adds a preference-based scoring algorithm to the EORTC measurement portfolio. It is built on the most widely used health-related quality of life (HRQoL) measure in oncology, the EORTC Quality of Life Questionnaire - Core 30 (QLQ-C30), allowing for the calculation of both HRQoL profiles and health utilities. This is an important advancement for integrating cancer-specific values into health economic evaluations and decision making, offering greater content validity and statistical power than some generic measures.
View Article and Find Full Text PDFParkinsonism Relat Disord
January 2025
Department of Neurology, Washington University School of Medicine in St. Louis, 660 S Euclid Ave, St. Louis, MO, 63110, USA. Electronic address:
Introduction: Neuroprotective therapy to slow Parkinson's disease (PD) progression is a critical unmet need. Neuroinflammation likely represents an important pathophysiologic mechanism for disease progression. Medications that target this inflammation, such as immunosuppressants, represent potential disease-modifying therapies for PD.
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