AI Article Synopsis
- 2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is a type of enzyme that helps in creating key components for organic chemistry by forming C-C bonds between acetaldehyde and other aldehydes.
- The enzyme's use in industry is limited due to its inability to tolerate high concentrations of aldehydes, particularly acetaldehyde.
- The review discusses the history and function of DERA, the challenges it faces with aldehyde resistance, and the optimization methods being researched to enhance its practical application.
Article Abstract
2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is a class I aldolase that offers access to several building blocks for organic synthesis. It catalyzes the stereoselective C-C bond formation between acetaldehyde and numerous other aldehydes. However, the practical application of DERA as a biocatalyst is limited by its poor tolerance towards industrially relevant concentrations of aldehydes, in particular acetaldehyde. Therefore, the development of proper experimental conditions, including protein engineering and/or immobilization on appropriate supports, is required. The present review is aimed to provide a brief overview of DERA, its history, and progress made in understanding the functioning of the enzyme. Furthermore, the current understanding regarding aldehyde resistance of DERA and the various optimizations carried out to modify this property are discussed.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244999 | PMC |
| http://dx.doi.org/10.1007/s00253-018-9392-8 | DOI Listing |
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