infection is a common cause of pneumonia in animals but rarely causes disease in humans. Additionally, coinfection with is very uncommon and is occasionally seen in patients with acquired immunodeficiency syndrome (AIDS). We report a case of a 61-year-old HIV-negative man, who presented with hypoxic respiratory failure 2 days after completion of systemic intravenous antibiotic treatment for His past medical history was significant for a benign thymoma. The patient was found to be coinfected with and Laboratory results showed panhypogammaglobulinemia and low absolute B- and CD4 T-cells. Therefore, the patient was diagnosed with Good's syndrome. However, despite treatment with intravenous antibiotics and intravenous immunoglobulin, the patient continued to deteriorate and expired. This patient demonstrates the importance of recognizing this rare immunodeficiency early in order to improve morbidity and mortality. Furthermore, this case highlights the importance of early immunoglobulin screening in the presence of asymptomatic thymoma.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166300 | PMC |
http://dx.doi.org/10.1177/2324709618802869 | DOI Listing |
BMJ Open
December 2024
Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Central, Uganda.
Introduction: Tuberculosis (TB) is the leading infectious cause of death globally. Despite WHO recommendations for TB preventive therapy (TPT), challenges persist, including incompletion of treatment and adverse drug reactions (ADRs). There is limited data on the 3-month isoniazid and rifapentine (3HP) pharmacokinetics, pharmacogenomics and their relation with ADRs.
View Article and Find Full Text PDFAnticancer Res
January 2025
Department of Integrated TCM & Western Medicine, The Affiliated Cancer Hospital of Nanjing Medical University and Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, P.R. China
Background/aim: Colorectal cancer (CRC) has the third-highest incidence among human cancers. Advancements in chemotherapy and targeted therapy have improved the treatment outcomes for patients with CRC. However, the management of patients with unresectable metastatic CRC (mCRC) continues to be a significant challenge for clinicians worldwide, particularly for those with microsatellite stability (MSS) and the BRAF V600E mutation, as they are associated with the poorest prognosis.
View Article and Find Full Text PDFBone Joint J
January 2025
King's Foot and Ankle Unit, King's College Hospital NHS Foundation Trust, London, UK.
Hallux valgus (HV) presents as a common forefoot deformity that causes problems with pain, mobility, footwear, and quality of life. The most common open correction used in the UK is the Scarf and Akin osteotomy, which has good clinical and radiological outcomes and high levels of patient satisfaction when used to treat a varying degrees of deformity. However, there are concerns regarding recurrence rates and long-term outcomes.
View Article and Find Full Text PDFPLOS Glob Public Health
December 2024
Research and Development Solutions, Islamabad, Pakistan.
Fertility patterns are transitioning globally in that couples are choosing to have fewer children as they become more affluent, and parents are investing more time and resources in the lives of their children than they can receive back. This change is more established in developed countries and is now being recognized in developing countries. We explored this phenomenon and its implications for family planning in Pakistan, hypothesizing a quantity-quality transition underway.
View Article and Find Full Text PDFAims: To determine patient and nursing factors associated with peripheral intravenous access success among hospitalised adults on medical-surgical units.
Design: A prospective, cross-sectional, correlational design was guided by STROBE.
Methods: Within a quaternary care hospital with multiple medical-surgical units, nurses who attempted intravenous access completed case report forms and medical records were reviewed to record 38 factors associated with intravenous access success.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!