AI Article Synopsis
- Scorpion stings from Tityus serrulatus venom can lead to severe cardiac issues, contributing significantly to mortality among victims.
- The study describes a newly identified toxin called CPP-Ts, which increases calcium release in heart cells, enhancing their contraction frequency.
- Additionally, CPP-Ts shows potential for use in drug delivery targeting cancer cell nuclei, highlighting a new subfamily of calcium-active toxins and their biotechnological applications.
Article Abstract
Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca channel toxin present in Tityus serrulatus (Ts) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increases intracellular Ca release through the activation of nuclear InsP3R of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells. Besides proposing a novel subfamily of Ca active toxins, we investigated its potential use as a drug delivery system targeting cancer cell nucleus using CPP-Ts's nuclear-targeting property. To this end, we prepared a synthetic CPP-Ts sub peptide lacking pharmacological activity which was directed to the nucleus of specific cancer cell lines. This research identifies a novel subfamily of Ca active toxins and provides new insights into biotechnological applications of animal venoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170434 | PMC |
| http://dx.doi.org/10.1038/s41598-018-33133-3 | DOI Listing |
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