AI Article Synopsis
- The study evaluated the long-term outcomes of children treated in utero for fetal chylothorax using OK-432 over a period from 2003 to 2009.
- Twelve out of fourteen children showed normal pulmonary function and IQ levels, with a median follow-up age of 11.4 years.
- The findings suggest that children treated with OK-432 have similar survival and neurodevelopmental outcomes compared to those receiving alternative treatments, with potentially lower risks of complications.
Article Abstract
Background: The treatment options for fetal chylothorax include thoracocentesis, thoracoamniotic shunting, and pleurodesis using OK-432. Knowledge on the long-term outcomes after treatment with OK-432 is limited.
Objective: The aim of this study was to assess the long-term outcomes of children treated in utero with OK-432.
Methods: We performed follow-up on pregnancies and children treated in utero with OK-432 between 2003 and 2009 at Copenhagen University Hospital Rigshospitalet for pleural effusions at gestational age (GA) 16+0-21+6 weeks. Anamnestic information, physical examination, pulmonary function test, neuropediatric examination, and intelligence testing using the Wechsler Intelligence Scale were used for evaluation.
Results: Fourteen cases, all chylothorax, were treated with OK-432. None had preterm premature rupture of membranes (PPROM), and the median GA at delivery was 38+5 (24+4-41+5) weeks. Twelve children were eligible for follow-up. The median age at follow-up was 11.4 (7.8-13.8) years. Pulmonary function was normal in all children and the mean full-scale IQ did not differ from that of normal children. Four children had a diagnosed medical condition, attention deficit disorder, or genetic syndrome. The remaining children had normal follow-up.
Conclusion: Children treated with OK-432 have comparable survival rates and long-term neurodevelopmental outcomes to those treated with thoracoamniotic shunts. There seems to be a lower risk of procedure-related PPROM.
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| http://dx.doi.org/10.1159/000489775 | DOI Listing |
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