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Controversy remains in understanding both the development and treatment for the odontogenic keratocyst (OKC). With recent changes in nomenclature recognizing the odontogenic keratocyst as a benign tumor, the debate over the proper course of treatment to limit recurrence and morbidity will continue. This study presents two cases where conservative treatment failed to prevent recurrence and each patient underwent resection of aggressive, multicystic OKCs to provide the best chance for definitive care without recurrence and limited morbidity.
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