Analyzing the autocorrelation function of the fluorescence intensity, we demonstrate that these nanoemitters are characterized by a short value of the mean duration of bright periods (ten to a few hundreds of microseconds). The comparison of the results obtained for samples with different geometries shows that not only the shell thickness is crucial but also the shape of the dot-in-rods. Increasing the shell aspect ratio results in shorter bright periods suggesting that surface traps impact the stability of the fluorescence intensity.
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http://dx.doi.org/10.1002/cphc.201800694 | DOI Listing |
Chemistry
January 2025
Shanghai Institute of Materia Medica Chinese Academy of Sciences, State Key Laboratory of Drug Research, CHINA.
The fluorescent imaging of pathologically accumulated β-amyloid (Aβ) proteins is of significant importance to the diagnosis of Alzheimer's disease (AD). In the paper, we prepared two new NIR probes, NIR-1 and NIR-2, through hydrophilic modification of introducing water-soluble bioactive groups such as polyethylene glycol (PEG) and morpholine to tune in vivo pharmacokinetics for specific detection of soluble and insoluble Aβ species. The in vitro assessments confirm that both NIR-1 and NIR-2 display strong near-infrared (NIR) fluorescence (FL) enhancement upon association with Aβ42 monomers, oligomers or aggregates (λem > 670 nm) and show high sensitive, rapid and selective response towards Aβ42 species.
View Article and Find Full Text PDFSmall
January 2025
Department of Chemistry and the MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
In this work, a site-selective functionalization strategy is proposed for modifying fluorescent dyes in the plasmonic nanopore, which highlights building optoelectronic dual-signal sensing interfaces at "hotspots" locations to construct multiparameter detection nanosensor. Finite-difference time-domain (FDTD) simulations confirmed the high-intensity electromagnetic field due to plasmonic nanostructure. It is demonstrated that adjusting the distance between the nanopore inner wall and fluorophore prevented the fluorescence quenching, resulting in more than a thirty fold fluorescence enhancement.
View Article and Find Full Text PDFSoft Matter
January 2025
INSERM (French National Institute of Health and Medical Research), UMR 1260, Regenerative Nanomedicine (RNM), FMTS, Université de Strasbourg, F-67000 Strasbourg, France.
Characterization of nanoscale formulations is a continuous challenge. Size, morphology and surface properties are the most common characterizations. However, physicochemical properties inside the nanoparticles, like viscosity, cannot be directly measured.
View Article and Find Full Text PDFRSC Adv
January 2025
Institute of Polymer and Dye Technology, Lodz University of Technology Stefanowskiego 16 Lodz 90537 Poland.
This study investigates the structure-property relationships of a series of phenylhydrazones bearing various electron-donating and electron-withdrawing substituents, such as methoxy, dimethylamino, morpholinyl, hydroxyl, chloro, bromo, and nitro groups. The compounds were synthesized, and their structures were characterized using single-crystal X-ray diffraction, powder X-ray diffraction, FTIR spectroscopy, NMR spectroscopy, and DSC. Three-dimensional excitation-emission matrix (3D-EEM) fluorescence spectroscopy and UV-Vis spectroscopy were employed to elucidate the complex interplay between the molecular skeleton, substituents, and the resulting photophysical properties.
View Article and Find Full Text PDFMediterr J Hematol Infect Dis
January 2025
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Italy.
Background: Clonal mature B-cell lymphoproliferative disorders (B-LPDs) are a heterogeneous group of neoplasia characterized by the proliferation of mature B lymphocytes in the peripheral blood, bone marrow and/or lymphoid tissues. B-LPDs classification into different subtypes and their diagnosis is based on a multiparametric approach. However, accurate diagnosis may be challenging, especially in cases of ambiguous interpretation.
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