It has become increasingly clear that the nonapeptide hormones oxytocin and vasopressin have more diverse behavioral and physiological effects across species and across individuals than was initially recognized. To reflect this variation, we would like to introduce our Special Issue, entitled Oxytocin and Vasopressin in Primate Behavior, by celebrating the diversity that is found across the articles within it. While every article directly addresses the topic of this Special Issue, they also vary in many characteristics: the species studied, the methods used, and the perspectives taken. By highlighting the interesting ways in which these articles differ from one another, we can gain unique insights into the subject that ties them together: our understanding of oxytocin and vasopressin and the behavior of primates. Nonhuman primates are critical intermediates between rodents and humans and are the best models for human biology and behavior, especially with respect to complex cognitive social constructs, such as visual social attention, face processing, and vocal communication. While rodent studies have laid an important and foundational framework for our understanding of nonapeptides, brains, and behavior, these studies cannot fully recapitulate human phenomena. Therefore, we hope the articles presented here contribute to a greater understanding on the role of oxytocin and vasopressin in primate physiology and behavior and help to further advance the application of this knowledge to human biology.
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http://dx.doi.org/10.1002/ajp.22919 | DOI Listing |
Horm Mol Biol Clin Investig
January 2025
Department of Biochemistry, Faculty of Medicine, 37555 Urmia University of Medical Sciences, Urmia, Iran.
Biochem Biophys Res Commun
January 2025
Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:
Pain is a major non-motor symptom of Parkinson's disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for oxytocin (OXT), but not yet for arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). The present study aimed to investigate the alterations in these neuropeptides following nociceptive stimulation in PD model rats and to examine the mechanisms of hyperalgesia.
View Article and Find Full Text PDFEndocrine
December 2024
Department of Neurosurgery, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland.
Purpose: Transient arginine vasopressin deficiency (AVP-D), previously called diabetes insipidus, is a well-known complication of transsphenoidal pituitary surgery (TPS) with no definite predictive biomarker to date making it difficult to anticipate. While oxytocin (OXT) was previously suggested as a possible biomarker to predict syndrome of inappropriate diuresis (SIAD)-related hyponatraemia after TPS, its secretion in patients presenting with AVP-D remains poorly understood. We therefore hypothesized that OXT might present a different secretion in the case of AVP-D which would support its potential as an early biomarker of AVP-D.
View Article and Find Full Text PDFJ Headache Pain
December 2024
Department of Clinical Sciences, Faculty of Medicine, Lund University, Getingevagen 4, Lund, 22185, Sweden.
Background: The purpose of this study was to examine whether there are sex differences in vasomotor responses and receptor localization of hormones and neuropeptides with relevance to migraine (vasopressin, oxytocin, estrogen, progesterone, testosterone, amylin, adrenomedullin and calcitonin gene-related peptide (CGRP)) in human intracranial arteries.
Methods: Human cortical cerebral and middle meningeal arteries were used in this study. The tissues were removed in conjunction with neurosurgery and donated with consent.
bioRxiv
November 2024
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
The transcription factor MYT1L supports proper neuronal differentiation and maturation during brain development. MYT1L haploinsufficiency results in a neurodevelopmental disorder characterized by intellectual disability, developmental delay, autism, behavioral disruptions, aggression, obesity and epilepsy. While MYT1L is expressed throughout the brain, how it supports proper neuronal function in distinct regions has not been assessed.
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