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Effect of dupilumab on otitis media associated with eosinophilic chronic rhinosinusitis.
Braz J Otorhinolaryngol
January 2025
Tokushima University Graduate School, Institute of Biomedical Sciences, Department of Otolaryngology-Head and Neck Surgery, Tokushima, Japan.
Objective: Eosinophilic Otitis Media (EOM) is an intractable disease caused by type 2 inflammation, such as Eosinophilic Chronic Rhinosinusitis (ECRS) and bronchial asthma. Biologics have recently been used to treat ECRS and bronchial asthma. Biologics are not indicated for EOM; however, because approximately 10% of ECRS cases has concomitant EOM, concomitant EOM improvement has been observed when dupilumab is administered for ECRS.
View Article and Find Full Text PDFGroup 3 Innate Lymphoid Cells: A Potential Therapeutic Target for Steroid Resistant Asthma.
Clin Rev Allergy Immunol
December 2024
Division of Allergy and Clinical Immunology, The Johns Hopkins Asthma & Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Room 3B.71, Baltimore, MD, 21224, USA.
Asthma is a chronic airway inflammatory disease that affects millions globally. Although glucocorticoids are a mainstay of asthma treatment, a subset of patients show resistance to these therapies, resulting in poor disease control and increased morbidity. The complex mechanisms underlying steroid-resistant asthma (SRA) involve Th1 and Th17 lymphocyte activity, neutrophil recruitment, and NLRP3 inflammasome activation.
View Article and Find Full Text PDFType 2 inflammation: a Portuguese consensus using Web-Delphi and decision conferencing (INFLAT2-PT).
Expert Rev Clin Immunol
January 2025
CEGIST-Centro de Estudos de Gestão, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.
Objectives: Atopic/allergic diseases impose a growing burden on public health, affecting millions of patients worldwide. The main objective of this study was to develop a national expert consensus on relevant clinical questions related to type 2 inflammation.
Methods: We conducted: a comprehensive literature review with a qualitative analysis to identify the most repeated themes on the overlap of conditions; a modified 3-round Web-Delphi (or e-Delphi); and a final online decision conference.
Strongyloides stercoralis infection in a patient initiating corticosteroid therapy for hypereosinophilia: A case report.
Parasitol Int
December 2024
Department of Medical Microbiology, Faculty of Medicine, TOBB University of Economics and Technology, Ankara, Turkey; Department of Medical Microbiology, Faculty of Medicine, Cyprus International University, Nicosia, Cyprus.
Strongyloides stercoralis (S. stercoralis) is a soil-transmitted nematode that is endemic to tropical and subtropical regions. S.
View Article and Find Full Text PDFACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis.
Am J Gastroenterol
January 2025
Kennth C. Griffin Esophageal Center, Division of Gastroenterology and Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Article Synopsis
- Eosinophilic esophagitis (EoE) is a chronic immune disease characterized by symptoms of esophageal dysfunction and an eosinophil-dominated infiltration in the esophagus.
- The incidence of EoE is rising, requiring attention in various medical settings, leading to updated guidelines that focus on improved diagnosis and treatment strategies.
- Recommended treatments include proton pump inhibitors, topical steroids, dietary elimination, and esophageal dilation, with an emphasis on monitoring patients for treatment response and managing both inflammatory and structural aspects of the disease.
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