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Megahertz serial crystallography. | LitMetric

AI Article Synopsis

  • The European X-ray Free-Electron Laser (XFEL) is the first of its kind to deliver X-ray pulses at megahertz pulse rates, vastly improving on previous technologies.
  • Researchers have successfully measured high-quality diffraction data at these new pulse rates, validating the laser's capabilities.
  • Two complete datasets were collected: one from lysozyme and another from a β-lactamase complex, demonstrating the potential for advanced structural analysis and dynamic measurements in molecular science.

Article Abstract

The new European X-ray Free-Electron Laser is the first X-ray free-electron laser capable of delivering X-ray pulses with a megahertz inter-pulse spacing, more than four orders of magnitude higher than previously possible. However, to date, it has been unclear whether it would indeed be possible to measure high-quality diffraction data at megahertz pulse repetition rates. Here, we show that high-quality structures can indeed be obtained using currently available operating conditions at the European XFEL. We present two complete data sets, one from the well-known model system lysozyme and the other from a so far unknown complex of a β-lactamase from K. pneumoniae involved in antibiotic resistance. This result opens up megahertz serial femtosecond crystallography (SFX) as a tool for reliable structure determination, substrate screening and the efficient measurement of the evolution and dynamics of molecular structures using megahertz repetition rate pulses available at this new class of X-ray laser source.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168542PMC
http://dx.doi.org/10.1038/s41467-018-06156-7DOI Listing

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